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Experts analyzed data from 61,377 T2DM patients to compare non-arteritic anterior ischemic optic neuropathy (NAION) risk between those starting semaglutide versus sodium-glucose co-transporter 2 inhibitors (SGLT-2is). NAION incidence rates were higher among semaglutide users. The pooled adjusted hazard ratio for NAION with semaglutide was 2.81. They concluded that despite the increased risk of NAOIN, the absolute risk remains low.

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Experts analyzed data from 61,377 T2DM patients to compare non-arteritic anterior ischemic optic neuropathy (NAION) risk between those starting semaglutide versus sodium-glucose co-transporter 2 inhibitors (SGLT-2is). NAION incidence rates were higher among semaglutide users. The pooled adjusted hazard ratio for NAION with semaglutide was 2.81. They concluded that despite the increased risk of NAOIN, the absolute risk remains low.
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