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Experts analyzed data from 745 patients with hormone receptor-positive, HER2-negative advanced breast cancer treated with CDK4/6 inhibitors and endocrine therapy. Real-world progression-free survival (rwPFS) varied by disease setting and treatment-free interval. Subsequent treatment outcomes were poor, especially with chemotherapy. These findings highlight the need for improved sequential strategies after initial CDK4/6i therapy.
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Experts analyzed data from 745 patients with hormone receptor-positive, HER2-negative advanced breast cancer treated with CDK4/6 inhibitors and endocrine therapy. Real-world progression-free survival (rwPFS) varied by disease setting and treatment-free interval. Subsequent treatment outcomes were poor, especially with chemotherapy. These findings highlight the need for improved sequential strategies after initial CDK4/6i therapy.
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