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Experts analyzed data from 745 patients with hormone receptor-positive, HER2-negative advanced breast cancer treated with CDK4/6 inhibitors and endocrine therapy. Real-world progression-free survival (rwPFS) varied by disease setting and treatment-free interval. Subsequent treatment outcomes were poor, especially with chemotherapy. These findings highlight the need for improved sequential strategies after initial CDK4/6i therapy.

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Experts analyzed data from 745 patients with hormone receptor-positive, HER2-negative advanced breast cancer treated with CDK4/6 inhibitors and endocrine therapy. Real-world progression-free survival (rwPFS) varied by disease setting and treatment-free interval. Subsequent treatment outcomes were poor, especially with chemotherapy. These findings highlight the need for improved sequential strategies after initial CDK4/6i therapy.
Today

The Central Drugs Standard Control Organisation has granted marketing authorization for Qdenga, marking India's first approved dengue vaccine. Developed by Takeda, this two-dose live-attenuated vaccine offers protection for individuals aged 4 to 60 without requiring prior serological screening.
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Johnson & Johnson announced a $5.5 billion settlement to resolve nearly 69,000 lawsuits alleging its talc-based baby powder caused ovarian cancer. This comprehensive deal covers 99.75% of active claims. Read about the legal strategy, scientific evidence on talc exposure, and clinical counseling for patients.
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Researchers at SGPGIMS Lucknow have isolated and cultured human heart valve interstitial cells from donor tissues. This milestone advances understanding of rheumatic heart disease pathways like TGF-beta/SMAD3 and ERK1/2, laying the foundation for tissue-engineered heart valves and drug testing.
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Anterior cruciate ligament reconstruction failure lacks uniform definition. A narrative review proposes an integrative framework incorporating objective and subjective instability, persistent pain, restricted motion, graft rupture, and secondary meniscal injury to standardize clinical reporting.
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Deepinder Goyal's healthtech startup Temple is raising capital at a $500 million valuation and pricing its temporal wearable at Rs 80,000. Worn on the side of the forehead, the device tracks microvascular blood flow and real-time Entropy to monitor physiological stress, metabolic expenditure, and recovery.
Today