
Loading, please wait...

Loading, please wait...

This meta-analysis of 6 trials assessed pyridostigmine for orthostatic hypotension (OH). Pyridostigmine alone showed a non-significant reduction in orthostatic BP drop. Combined with midodrine, it significantly improved systolic orthostatic drop. Pyridostigmine minimally affected supine BP and had few side effects. It may be particularly beneficial for patients with preserved baroreflex function and those at risk of supine hypertension.

Read summarized clinical updates, watch expert medical content, and earn CME certifications right from your smartphone.


This meta-analysis of 6 trials assessed pyridostigmine for orthostatic hypotension (OH). Pyridostigmine alone showed a non-significant reduction in orthostatic BP drop. Combined with midodrine, it significantly improved systolic orthostatic drop. Pyridostigmine minimally affected supine BP and had few side effects. It may be particularly beneficial for patients with preserved baroreflex function and those at risk of supine hypertension.
4 months ago

Dendritic cells bridge innate and adaptive immunity in myocardial infarction. This review explores their pathological roles, circulating dynamics, novel tolerogenic interventions, and how standard cardiovascular medications modulate dendritic cells to improve post-infarction myocardial repair and patient outcomes.
Today

A premature neonate developed upper limb compartment syndrome after uterine rupture extruded the arm through a scar defect. Conservative management with continuous monitoring yielded complete functional recovery and normal limb growth at 10-year follow-up, highlighting non-operative safety in selected cases.
Today

Atherosclerosis involves extensive glycometabolic reprogramming across immune and vascular cells. This review examines how glycolysis, the pentose phosphate pathway, and lactate-driven epigenetic shifts fuel plaque vulnerability, while highlighting novel therapeutic targets like PFKFB3 and LDHA.
Today

Endoscopic posterior cervical fusion combines minimally invasive decompression, joint preparation, and rigid screw-rod fixation for atlantoaxial pathologies. Early clinical findings demonstrate solid bony union, excellent symptom relief, and minimal soft-tissue morbidity without significant vascular compromise.
Yesterday

The All-India Food Processors' Association has approached the Supreme Court to oppose FSSAI's proposed per-100g benchmark for front-of-pack warning labels, advocating instead for a per-serving threshold. We explore the regulatory showdown, nutritional evidence, and implications for clinical lifestyle counseling.
Today