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Alcohol-induced gastric damage remains a significant clinical challenge for healthcare providers globally. Recent scientific breakthroughs suggest that a novel alcoholic gastric ulcer treatment using Lactobacillus rhamnosus JM023 postbiotics could transform patient care. Conventional synthetic drugs often struggle with low bioavailability and high gastrointestinal toxicity. Consequently, researchers have engineered a sodium alginate-based hydrogel to overcome these pharmaceutical barriers.
This composite hydrogel functions as a microenvironment-responsive delivery system. Notably, the material maintains more than 95% of its mass during simulated digestion. Therefore, it ensures the targeted release of postbiotics directly to the gastric mucosa. The hydrogel significantly reduces the ulcerated area while suppressing active bleeding. Furthermore, it enhances antioxidant enzymes like SOD and CAT. This process effectively neutralizes reactive oxygen species that cause tissue destruction.
Beyond local protection, the hydrogel modulates critical intracellular signaling pathways. Specifically, it downregulates pro-inflammatory cytokines like TNF-α and IL-6 through the NF-κB and Nrf2/HO-1 axes. In addition to these anti-inflammatory effects, the treatment restores gut microbiota homeostasis. It promotes the growth of beneficial genera such as Allobaculum and Lactobacillus. This dual-targeted approach addresses both local injury and systemic microbial health.
Postbiotics offer several advantages over live probiotics, including improved shelf-life and safety profiles. In this study, the JM023 strain demonstrated exceptional biocompatibility. Since the hydrogel exhibits a very low hemolysis rate, it remains safe for systemic use. Ultimately, this research provides a robust framework for developing advanced biomaterials to treat alcohol-induced mucosal injuries.
The hydrogel acts as a physical barrier and a bioactive delivery system. It releases postbiotics that boost antioxidant levels and lower inflammation, which directly repairs the gastric lining.
Sodium alginate provides excellent mechanical stability and slow degradation. These properties allow the treatment to persist in the harsh gastric environment, ensuring the therapeutic agents reach the ulcer site effectively.
Disclaimer: This content is for informational and educational purposes only. It does not constitute medical advice or a professional recommendation. The information provided should not be used to diagnose or treat a health problem or disease. Refer to the latest local and national guidelines for clinical practice.
References
Li Y et al. Lactobacillus rhamnosus JM023 Postbiotic-Loaded Sodium Alginate Hydrogel for Alleviating Alcoholic Gastric Ulcers. Adv Healthc Mater. 2026 May 10. doi: 10.1002/adhm.71236. PMID: 42106931.
Wu Y et al. Lactobacillus plantarum ZS62 Alleviates Alcohol-Induced Gastric Injury in Mice via an Anti-Oxidative Mechanism. Drug Des Devel Ther. 2021;15:1667-1676.
Lam EKW et al. Probiotic Lactobacillus rhamnosus GG enhances gastric ulcer healing in rats. Eur J Pharmacol. 2007;565(1-3):166-174.
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