.webp&w=384&q=75){kind=logo}
Loading, please wait...
Loading, please wait...
Clinicians often face significant challenges in predicting liver recovery after complex procedures like ALPPS. Consequently, identifying reliable biomarkers is essential for effective patient selection and planning. This study highlights how NRS-2002 hepatic regeneration assessments can provide valuable prognostic information for patients with HBV-related HCC.
Researchers identified three primary preoperative risk factors for delayed liver growth. Specifically, an NRS-2002 score of 3 or higher, the presence of resected-side portal vein thrombosis (PVT), and decreased prealbumin levels significantly correlated with prolonged intervals to adequate regeneration. Moreover, the developed nomogram demonstrated an impressive exploratory accuracy with an Area Under the Curve (AUC) of 0.905.
Furthermore, patients with lower nutritional risk scores generally experienced better survival outcomes compared to those with higher scores. Effective nutritional screening allows surgeons to mitigate risks before proceeding to the second stage of the hepatectomy. However, the study\'s modest sample size suggests that practitioners should exercise caution and wait for external validation before routine clinical application.
A high NRS-2002 score (≥3) indicates a significant nutritional risk. This factor is independently linked to delayed hepatic regeneration following the first stage of the ALPPS procedure in HBV-related HCC cases.
Prealbumin serves as a sensitive indicator of both nutritional status and the liver\'s protein-synthesizing capacity. Lower preoperative levels often signal a higher risk of prolonged intervals required for the liver to reach an adequate volume for the final surgical stage.
Disclaimer: This content is for informational and educational purposes only. It does not constitute medical advice or a substitute for professional healthcare consultation. Refer to the latest local and national guidelines for clinical practice.
References
Zhu W et al. Nutritional Risk Predicts Hepatic Regeneration After Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy in HBV-related HCC. Arch Med Res. 2026 Jun 09. doi: undefined. PMID: 42263344.
Li J et al. Application of associating liver partition and portal vein ligation for staged hepatectomy for initially unresectable hepatocellular carcinoma. BMC Cancer. 2022;22:1240. doi: 10.1186/s12885-022-10332-6.
"
Read summarized clinical updates, watch expert medical content, and earn CME certifications right from your smartphone.
Open your smartphone camera to scan and install.
Study finds NRS-2002 score, prealbumin, and PVT as key predictors for delayed hepatic regeneration in HBV-related HCC patients undergoing ALPPS....
last month
Andhra Pradesh reported 10 new Covid-19 cases, taking the state tally to 49 while deaths remain at four. With 24 patients hospitalized and 16 under home isolation, the Health Department has intensified monitoring. Medical professionals should review regional distribution, diagnostic protocols, and management plans.
Today
An 11-year Swedish registry study of 618 uterine sarcoma patients found that minimally invasive surgery yielded survival comparable to open surgery in early stages. However, adjuvant chemotherapy conferred no survival benefit in localized or advanced disease, highlighting stage and histology as key outcomes.
3 days back
A cross-sectional study evaluates post-intensive care syndrome in cardiac patients 2-4 weeks post-ICU discharge, highlighting cognitive, psychological, and functional impairments and the need for structured multidisciplinary rehabilitation.
3 days back
Anterior cruciate ligament reconstruction failure lacks uniform definition. A narrative review proposes an integrative framework incorporating objective and subjective instability, persistent pain, restricted motion, graft rupture, and secondary meniscal injury to standardize clinical reporting.
3 days back
With World Obesity Atlas data warning that over 41 million Indian children are overweight or obese, ICMR and NIN have unveiled a 10-point policy roadmap. The initiative calls for mandatory front-of-pack labeling, HFSS taxes, strict marketing bans, and healthier school environments to curb non-communicable diseases.
Today
