.webp&w=384&q=75){kind=logo}
Loading, please wait...
Loading, please wait...
Clinicians often face significant challenges in predicting liver recovery after complex procedures like ALPPS. Consequently, identifying reliable biomarkers is essential for effective patient selection and planning. This study highlights how NRS-2002 hepatic regeneration assessments can provide valuable prognostic information for patients with HBV-related HCC.
Researchers identified three primary preoperative risk factors for delayed liver growth. Specifically, an NRS-2002 score of 3 or higher, the presence of resected-side portal vein thrombosis (PVT), and decreased prealbumin levels significantly correlated with prolonged intervals to adequate regeneration. Moreover, the developed nomogram demonstrated an impressive exploratory accuracy with an Area Under the Curve (AUC) of 0.905.
Furthermore, patients with lower nutritional risk scores generally experienced better survival outcomes compared to those with higher scores. Effective nutritional screening allows surgeons to mitigate risks before proceeding to the second stage of the hepatectomy. However, the study\'s modest sample size suggests that practitioners should exercise caution and wait for external validation before routine clinical application.
A high NRS-2002 score (≥3) indicates a significant nutritional risk. This factor is independently linked to delayed hepatic regeneration following the first stage of the ALPPS procedure in HBV-related HCC cases.
Prealbumin serves as a sensitive indicator of both nutritional status and the liver\'s protein-synthesizing capacity. Lower preoperative levels often signal a higher risk of prolonged intervals required for the liver to reach an adequate volume for the final surgical stage.
Disclaimer: This content is for informational and educational purposes only. It does not constitute medical advice or a substitute for professional healthcare consultation. Refer to the latest local and national guidelines for clinical practice.
References
Zhu W et al. Nutritional Risk Predicts Hepatic Regeneration After Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy in HBV-related HCC. Arch Med Res. 2026 Jun 09. doi: undefined. PMID: 42263344.
Li J et al. Application of associating liver partition and portal vein ligation for staged hepatectomy for initially unresectable hepatocellular carcinoma. BMC Cancer. 2022;22:1240. doi: 10.1186/s12885-022-10332-6.
"
Read summarized clinical updates, watch expert medical content, and earn CME certifications right from your smartphone.
Open your smartphone camera to scan and install.
Study finds NRS-2002 score, prealbumin, and PVT as key predictors for delayed hepatic regeneration in HBV-related HCC patients undergoing ALPPS....
3 months ago
Explore the emerging role of Brixadi, an extended-release buprenorphine injection, for managing stimulant use disorder through kappa opioid receptor antagonism and steady plasma levels.
Today
A premature neonate developed upper limb compartment syndrome after uterine rupture extruded the arm through a scar defect. Conservative management with continuous monitoring yielded complete functional recovery and normal limb growth at 10-year follow-up, highlighting non-operative safety in selected cases.
Today
Dendritic cells bridge innate and adaptive immunity in myocardial infarction. This review explores their pathological roles, circulating dynamics, novel tolerogenic interventions, and how standard cardiovascular medications modulate dendritic cells to improve post-infarction myocardial repair and patient outcomes.
Today
Endoscopic posterior cervical fusion combines minimally invasive decompression, joint preparation, and rigid screw-rod fixation for atlantoaxial pathologies. Early clinical findings demonstrate solid bony union, excellent symptom relief, and minimal soft-tissue morbidity without significant vascular compromise.
Yesterday
Atherosclerosis involves extensive glycometabolic reprogramming across immune and vascular cells. This review examines how glycolysis, the pentose phosphate pathway, and lactate-driven epigenetic shifts fuel plaque vulnerability, while highlighting novel therapeutic targets like PFKFB3 and LDHA.
Today
