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LRPPRC acts as an m6A reader protein that stabilizes specific mRNAs like PCDH7. This stabilization promotes tumor growth by enhancing glycolysis and preventing ferroptosis.
GATA3 is a transcription factor that directly stimulates the production of LRPPRC. This increase in LRPPRC levels fuels metabolic pathways that allow glioma cells to survive and proliferate.
Disclaimer: This content is for informational and educational purposes only. It does not constitute professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Refer to the latest local and national guidelines for clinical practice.
References
Sun Y et al. Leucine-rich pentatricopeptide repeat-containing protein silencing transcriptionally regulated by GATA-binding protein 3 has an anti-glioma effect by regulating glycolysis and ferroptosis by mediating N6-methyladenosine modification of protocadherin-7. J Neuropathol Exp Neurol. 2026 May 04. doi: undefined. PMID: 42081257.
Wang J et al. The m6A Reader LRPPRC Promotes Cancer Progression by Regulating Metabolic Pathways. Frontiers in Oncology. 2024.
Liu H et al. Deciphering the Link: Ferroptosis and its Role in Glioma. Frontiers in Cell and Developmental Biology. 2023.

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