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A meta-analysis of 18 randomized controlled trials involving 22,429 migraine patients compares the outcomes of lasmiditan, rimegepant, ubrogepant, and zavegepant for acute migraine management. Rimegepant (75 mg) and ubrogepant (100 mg) emerge as favorable options with both efficacy and tolerability. Lasmiditan (100 mg and 200 mg) shows notable efficacy but is associated with a higher risk of adverse events.

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A meta-analysis of 18 randomized controlled trials involving 22,429 migraine patients compares the outcomes of lasmiditan, rimegepant, ubrogepant, and zavegepant for acute migraine management. Rimegepant (75 mg) and ubrogepant (100 mg) emerge as favorable options with both efficacy and tolerability. Lasmiditan (100 mg and 200 mg) shows notable efficacy but is associated with a higher risk of adverse events.
last month

A recent study highlights the utility of two-dimensional speckle tracking echocardiography in assessing right atrial mechanics in OSAHS. Progressive reductions in reservoir and conduit strain, coupled with elevated contraction strain, signal early right heart remodeling correlated with apnea severity.
Today

A multicentre RCT in China shows that the PAICS AI system significantly boosts sonographer sensitivity in detecting fetal intracranial malformations by 8.7% without compromising specificity, offering promising diagnostic support for prenatal neurosonography.
Today

A 2026 meta-analysis evaluates PDE5 inhibitors in advanced ILD with severe gas exchange impairment. While overall mortality was not significantly reduced, a targeted subgroup with pulmonary hypertension showed a 49% risk reduction, underscoring the necessity of precise hemodynamic phenotyping.
Today

A premature neonate developed upper limb compartment syndrome after uterine rupture extruded the arm through a scar defect. Conservative management with continuous monitoring yielded complete functional recovery and normal limb growth at 10-year follow-up, highlighting non-operative safety in selected cases.
Yesterday

The Supreme Court questioned FSSAI's phased warning approach, urging single-phase implementation for foods exceeding limits in any nutrient of concern. Backed by ICMR-NIN recommendations, the proposed red hexagonal warnings target added sugar, salt, and fat to combat India's escalating chronic disease epidemic.
Today