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This randomized clinical trial evaluated whether a decision-support system could help clinicians and patients select antidepressant treatment for major depressive disorder more effectively than usual care. The tool was designed to support shared decision-making by presenting personalised treatment information during consultations. The study assessed clinical outcomes alongside treatment selection and patient involvement in decisions. It is particularly relevant because antidepressant choice in routine practice is often guided by trial and error, and patients may discontinue or switch treatment when the initial medication is ineffective or poorly tolerated. When interpreting this study, the distinction between improvement in decision quality and improvement in depressive symptoms is important: a decision-support tool may help clinicians make more informed choices, but its value ultimately depends on whether it improves outcomes that matter to patients. See the original report for the trial’s primary endpoint and numerical between-group results before drawing conclusions about clinical benefit.
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This randomized clinical trial evaluated whether a decision-support system could help clinicians and patients select antidepressant treatment for major depressive disorder more effectively than usual care. The tool was designed to support shared decision-making by presenting personalised treatment information during consultations. The study assessed clinical outcomes alongside treatment selection and patient involvement in decisions. It is particularly relevant because antidepressant choice in routine practice is often guided by trial and error, and patients may discontinue or switch treatment when the initial medication is ineffective or poorly tolerated. When interpreting this study, the distinction between improvement in decision quality and improvement in depressive symptoms is important: a decision-support tool may help clinicians make more informed choices, but its value ultimately depends on whether it improves outcomes that matter to patients. See the original report for the trial’s primary endpoint and numerical between-group results before drawing conclusions about clinical benefit.
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