.webp&w=384&q=75){kind=logo}
Loading, please wait...
Loading, please wait...
Ewing sarcoma usually affects bone, but rectal Ewing sarcoma is a different clinical entity. Specifically, it presents as a rare extraosseous tumor. Recently, a 38-year-old male reported rectal bleeding. Consequently, a physical exam revealed an ulcerated rectal polyp near the dentate line. Because the lesion was ulcerated, doctors performed an excisional biopsy. Subsequent analysis showed a monotonous round cell malignancy involving the submucosal tissue. Moreover, the tumor exhibited necrosis and marked mitotic activity. Therefore, the pathology team used immunohistochemical studies to narrow the diagnosis.
Notably, the tumor cells reacted strongly to CD99 and NKX2.2. Furthermore, the clinical team utilized next-generation sequencing for definitive proof. Specifically, the test identified an EWSR1::FLI1 fusion variant junction in exon 7 for EWSR1 and exon 6 for FLI1. Because this fusion is pathognomonic for the Ewing family of tumors, it confirmed the diagnosis. Additionally, subsequent imaging showed no evidence of metastatic disease. Consequently, the patient underwent a successful re-excision. Finally, the procedure confirmed that there was no residual tumor.
Pathologists identify these tumors by looking for monotonous round cells. Moreover, they use markers like CD99 and NKX2.2. However, molecular confirmation of EWSR1 fusions is often necessary.
No, it is extremely rare. Specifically, this is only the second molecularly confirmed case of a superficial rectal primary tumor described in medical literature.
Disclaimer: This content is for informational and educational purposes only. It does not constitute professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Refer to the latest local and national guidelines for clinical practice.
References
Read summarized clinical updates, watch expert medical content, and earn CME certifications right from your smartphone.
Open your smartphone camera to scan and install.
This case report highlights a rare superficial rectal Ewing sarcoma in a 38-year-old male, emphasizing the critical role of molecular fusion identification....
4 months ago
A new study reveals that lipid-related metabolic dysregulation, marked by elevated TG/HDL-C ratio and glymphatic changes, independently impacts survival in idiopathic normal pressure hydrocephalus.
Today
A premature neonate developed upper limb compartment syndrome after uterine rupture extruded the arm through a scar defect. Conservative management with continuous monitoring yielded complete functional recovery and normal limb growth at 10-year follow-up, highlighting non-operative safety in selected cases.
Today
A meta-analysis of 13 propensity score-matched studies shows ViV-TAVR delivers lower early mortality and reduced bleeding compared to redo-SAVR for degenerated bioprosthetic aortic valves, though long-term hemodynamics warrant careful anatomical and patient-centered evaluation.
Today
Endoscopic posterior cervical fusion combines minimally invasive decompression, joint preparation, and rigid screw-rod fixation for atlantoaxial pathologies. Early clinical findings demonstrate solid bony union, excellent symptom relief, and minimal soft-tissue morbidity without significant vascular compromise.
Yesterday
The All-India Food Processors' Association has approached the Supreme Court to oppose FSSAI's proposed per-100g benchmark for front-of-pack warning labels, advocating instead for a per-serving threshold. We explore the regulatory showdown, nutritional evidence, and implications for clinical lifestyle counseling.
Today
