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The IMS-IMWG 2025 staging system provides a vital tool for managing newly diagnosed multiple myeloma (NDMM). This model integrates genomic data to define high-risk (HR) subsets accurately. Furthermore, clinicians now use this system to improve consistency in clinical trial reporting. Researchers recently validated these criteria in patients receiving daratumumab-based quadruplet therapy.
Specifically, a study analyzed 503 NDMM patients at Memorial Sloan Kettering Cancer Center. These patients underwent induction with anti-CD38 monoclonal antibody quadruplets. Consequently, findings showed that the new definition delineates risk better than legacy scores. Notably, the criteria identified 31% of patients as high-risk.
Although modern therapy is potent, survival differences remain significant. Interestingly, the IMS-IMWG 2025 staging did not predict early minimal-residual disease (MRD) negativity. HR and standard-risk (SR) patients reached MRD negativity at nearly identical rates. However, the genomic staging strongly predicted long-term survival outcomes.
Specifically, HR patients had a median progression-free survival (PFS) of only 2.6 years. In contrast, the median PFS for SR patients was not reached (p < 0.001). Moreover, the model predicted overall survival (OS) with high statistical significance (p = 0.003). Therefore, this staging system is essential for identifying patients who require closer monitoring or novel interventions.
It is the first to include TP53 mutations and specific co-occurrences of IgH translocations with chromosome 1 aberrations.
Yes, the study demonstrated that the genomic criteria effectively predict both progression-free survival and overall survival.
Disclaimer: This content is for informational and educational purposes only. It is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Refer to the latest local and national guidelines for clinical practice.
References
Maclachlan KH et al. IMS-IMWG 2025 consensus genomic staging predicts outcomes with daratumumab-based quadruplet regimens for NDMM. Blood Adv. 2026 Feb 17. doi: undefined. PMID: 41701976.
Avet-Loiseau H, et al. International Myeloma Society/International Myeloma Working Group Consensus Recommendations on the Definition of High-Risk Multiple Myeloma. J Clin Oncol. 2025;43(24):2739-2751.
International Myeloma Foundation. IMS-IMWG Consensus Definition of HRMM. June 2025.
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The new IMS-IMWG 2025 consensus genomic staging effectively predicts survival in NDMM patients treated with daratumumab-based quadruplet regimens....
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