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The authors assessed health-related quality of life (HRQoL) progression and identified influencing factors in 835 spinocerebellar ataxia (SCA) patients. HRQoL declined over time, with ataxia severity & mental health strongly correlated with HRQoL. Male patients with early disease onset experienced more intensive decline. Mental health & weight influence could be key areas for improving HRQoL in SCA, especially in male patients with early onset.

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The authors assessed health-related quality of life (HRQoL) progression and identified influencing factors in 835 spinocerebellar ataxia (SCA) patients. HRQoL declined over time, with ataxia severity & mental health strongly correlated with HRQoL. Male patients with early disease onset experienced more intensive decline. Mental health & weight influence could be key areas for improving HRQoL in SCA, especially in male patients with early onset.
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