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Recent research has scrutinized the high dose theacrine impact on human physiology. Consequently, scientists aimed to clarify how these concentrations affect stress markers and heart health. Notably, the study focused on habitual caffeine consumers who underwent a seven-day washout period. However, the results revealed a significant increase in salivary cortisol levels following treatment. Specifically, cortisol concentrations rose at 120 and 180 minutes post-treatment compared to the placebo group. Furthermore, heart rate and blood pressure remained remarkably stable throughout the observation period.
In contrast, cognitive performance did not show significant improvement across the different tested doses. Therefore, the study suggests that theacrine primarily influences the endocrine stress response at higher levels. Additionally, the effect on subjective energy remains unclear as only the placebo group showed improvement. This investigation is the first to analyze a theacrine-exclusive supplement regarding salivary alpha-amylase and cortisol. Overall, while cortisol increased, the substance did not negatively affect hemodynamic measures even at doses of 9 mg/kg.
No, the study found that high doses of theacrine do not significantly impact heart rate or blood pressure in healthy adults.
Research indicates that higher doses of theacrine can increase salivary cortisol concentrations at 120 and 180 minutes after consumption.
Disclaimer: This content is for informational and educational purposes only. It does not constitute professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Refer to the latest local and national guidelines for clinical practice.
References
Stoke CM et al. Assessing the Impact of High Theacrine Doses on Hemodynamic Measures, Cognitive Performance, and Physiological Stress. Appl Physiol Nutr Metab. 2026 Apr 08. doi: 10.1139/apnm-2025-0380. PMID: 41950524.
He H et al. Theacrine From Camellia kucha and Its Health Beneficial Effects. Front Pharmacol. 2020 Dec 17;11:596823. doi: 10.3389/fphar.2020.596823.
Kuhman DJ et al. Cognitive Performance and Mood Following Ingestion of a Theacrine-Containing Dietary Supplement, Caffeine, or Placebo by Young Men and Women. Nutrients. 2015 Nov 19;7(11):9618-32. doi: 10.3390/nu7115484.
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