.webp&w=384&q=75){kind=logo}
Loading, please wait...
Loading, please wait...
The PROSEVA trial transformed the role of prone positioning in severe ARDS. Adults with severe hypoxaemic ARDS were randomised to repeated prone-positioning sessions lasting at least 16 hours or to continued supine ventilation. Both groups received lung-protective ventilation, creating a clinically relevant comparison within modern ARDS care. Early, prolonged proning significantly reduced mortality, with the strongest benefit seen in severe ARDS. The physiologic rationale is that turning the patient prone redistributes stress and strain within the lung, improves ventilation-perfusion matching and can reduce regional overdistension while recruiting dependent lung units. The practical message is that proning is not merely a rescue manoeuvre for refractory hypoxaemia; in appropriately selected patients with severe ARDS, it is an evidence-based treatment that should be started early and delivered for sufficiently long sessions. Successful implementation depends on trained staff, airway security, pressure-injury prevention and coordinated monitoring. PROSEVA also demonstrates why individual components of ARDS care should not be interpreted in isolation—the mortality benefit emerged in the context of low tidal-volume ventilation and other supportive measures. For clinicians, prolonged prone positioning remains one of the highest-yield nonpharmacologic interventions for severe ARDS.
Read summarized clinical updates, watch expert medical content, and earn CME certifications right from your smartphone.
Open your smartphone camera to scan and install.
The PROSEVA trial transformed the role of prone positioning in severe ARDS. Adults with severe hypoxaemic ARDS were randomised to repeated prone-positioning sessions lasting at least 16 hours or to continued supine ventilation. Both groups received lung-protective ventilation, creating a clinically relevant comparison within modern ARDS care. Early, prolonged proning significantly reduced mortality, with the strongest benefit seen in severe ARDS. The physiologic rationale is that turning the patient prone redistributes stress and strain within the lung, improves ventilation-perfusion matching and can reduce regional overdistension while recruiting dependent lung units. The practical message is that proning is not merely a rescue manoeuvre for refractory hypoxaemia; in appropriately selected patients with severe ARDS, it is an evidence-based treatment that should be started early and delivered for sufficiently long sessions. Successful implementation depends on trained staff, airway security, pressure-injury prevention and coordinated monitoring. PROSEVA also demonstrates why individual components of ARDS care should not be interpreted in isolation—the mortality benefit emerged in the context of low tidal-volume ventilation and other supportive measures. For clinicians, prolonged prone positioning remains one of the highest-yield nonpharmacologic interventions for severe ARDS.
Today
The phase 3 ACACIA-HCM trial reveals that aficamten improves cardiac structure, diastolic relaxation, functional capacity, and symptom burden in symptomatic nonobstructive hypertrophic cardiomyopathy, marking a major milestone in targeted myosin inhibition.
6 days back
A clinical study shows that automated breast ultrasound paired with artificial intelligence accurately classifies BIRADS 3-4 lesions, reaching 95% sensitivity and 79% specificity. This diagnostic advance promises to reduce unnecessary core needle biopsies and refine clinical workflows in breast imaging.
3 weeks back
Researchers have engineered freestanding hierarchical-porous BCZT thin films that resist cracking and enhance ultrasonic energy harvesting in soft tissue. Achieving high piezoelectric output and acoustic matching, this lead-free material offers transformative potential for implantable bioelectronics.
6 days back
A novel pathology-adaptive surface engineering strategy uses functionalized plasma polymer coatings to selectively modulate AGE adsorption, reducing oxidative stress and restoring bone formation in diabetic and aging microenvironments.
3 weeks back
A breakthrough study identifies the Klotho/PKCα/CUX1/SPARC/TGFβ-RII axis as a critical driver of podocyte mitochondrial injury and ferroptosis in diabetic kidney disease, unveiling promising molecular targets to halt renal disease progression.
6 days back
