.webp&w=384&q=75){kind=logo}
Loading, please wait...
Loading, please wait...
A South Indian tertiary-center study examined infectious keratitis occurring after corneal collagen cross-linking (CXL) over a 10-year period. Among 3,842 in-house CXL procedures, 11 eyes developed post-CXL infectious keratitis, indicating a low incidence but clinically significant complication. The microbiological profile included bacterial organisms as well as fungal infections, and many affected eyes presented very early after treatment. The study is particularly relevant to high-volume corneal practices because it turns a rare complication into a practical postoperative surveillance issue. CXL involves epithelial disruption in many protocols, and the immediate postoperative period is therefore critical for recognizing infection, delayed epithelial healing, or stromal inflammation. The publication highlights the importance of patient counseling, sterile technique, appropriate antimicrobial prophylaxis according to local practice, and prompt reassessment when pain, infiltrate, hypopyon, or worsening vision occurs. The findings also reinforce that apparent post-CXL haze should not automatically be assumed to be a sterile phenomenon. Early differentiation between expected healing, sterile inflammation, and infectious keratitis can change the clinical trajectory and reduce the risk of corneal melt, scarring, or emergency therapeutic transplantation.
Read summarized clinical updates, watch expert medical content, and earn CME certifications right from your smartphone.
Open your smartphone camera to scan and install.
A South Indian tertiary-center study examined infectious keratitis occurring after corneal collagen cross-linking (CXL) over a 10-year period. Among 3,842 in-house CXL procedures, 11 eyes developed post-CXL infectious keratitis, indicating a low incidence but clinically significant complication. The microbiological profile included bacterial organisms as well as fungal infections, and many affected eyes presented very early after treatment. The study is particularly relevant to high-volume corneal practices because it turns a rare complication into a practical postoperative surveillance issue. CXL involves epithelial disruption in many protocols, and the immediate postoperative period is therefore critical for recognizing infection, delayed epithelial healing, or stromal inflammation. The publication highlights the importance of patient counseling, sterile technique, appropriate antimicrobial prophylaxis according to local practice, and prompt reassessment when pain, infiltrate, hypopyon, or worsening vision occurs. The findings also reinforce that apparent post-CXL haze should not automatically be assumed to be a sterile phenomenon. Early differentiation between expected healing, sterile inflammation, and infectious keratitis can change the clinical trajectory and reduce the risk of corneal melt, scarring, or emergency therapeutic transplantation.
Today
The phase 3 ACACIA-HCM trial reveals that aficamten improves cardiac structure, diastolic relaxation, functional capacity, and symptom burden in symptomatic nonobstructive hypertrophic cardiomyopathy, marking a major milestone in targeted myosin inhibition.
6 days back
A clinical study shows that automated breast ultrasound paired with artificial intelligence accurately classifies BIRADS 3-4 lesions, reaching 95% sensitivity and 79% specificity. This diagnostic advance promises to reduce unnecessary core needle biopsies and refine clinical workflows in breast imaging.
3 weeks back
Researchers have engineered freestanding hierarchical-porous BCZT thin films that resist cracking and enhance ultrasonic energy harvesting in soft tissue. Achieving high piezoelectric output and acoustic matching, this lead-free material offers transformative potential for implantable bioelectronics.
6 days back
A novel pathology-adaptive surface engineering strategy uses functionalized plasma polymer coatings to selectively modulate AGE adsorption, reducing oxidative stress and restoring bone formation in diabetic and aging microenvironments.
3 weeks back
A breakthrough study identifies the Klotho/PKCα/CUX1/SPARC/TGFβ-RII axis as a critical driver of podocyte mitochondrial injury and ferroptosis in diabetic kidney disease, unveiling promising molecular targets to halt renal disease progression.
6 days back
