
Loading, please wait...

Loading, please wait...

This randomized trial directly compared gastric bypass with sleeve gastrectomy in adults with moderately obese, poorly controlled type 2 diabetes. The study asked whether the two operations produce similar metabolic effects even when performed in patients who do not necessarily meet the very highest BMI thresholds associated with bariatric surgery. At one year, diabetes remission was markedly more frequent after gastric bypass than after sleeve gastrectomy in the study population. Both procedures produced metabolic improvements, but bypass demonstrated a stronger effect on glycaemic control. The findings are clinically relevant because they reinforce the concept of metabolic surgery as a therapeutic option for selected patients with type 2 diabetes, not simply as a treatment for severe obesity. At the same time, the trial was relatively small and had a short follow-up compared with major long-term bariatric studies, so its findings should be interpreted within the broader evidence base. For surgeons, procedure selection should remain individualized. Diabetes duration, endogenous insulin reserve, BMI, reflux, nutritional risk and patient preferences all influence the choice between procedures. The practical lesson is that sleeve gastrectomy and gastric bypass can have different metabolic profiles, and the patient's dominant clinical problem—not weight alone—should inform operative planning.

Read summarized clinical updates, watch expert medical content, and earn CME certifications right from your smartphone.


This randomized trial directly compared gastric bypass with sleeve gastrectomy in adults with moderately obese, poorly controlled type 2 diabetes. The study asked whether the two operations produce similar metabolic effects even when performed in patients who do not necessarily meet the very highest BMI thresholds associated with bariatric surgery. At one year, diabetes remission was markedly more frequent after gastric bypass than after sleeve gastrectomy in the study population. Both procedures produced metabolic improvements, but bypass demonstrated a stronger effect on glycaemic control. The findings are clinically relevant because they reinforce the concept of metabolic surgery as a therapeutic option for selected patients with type 2 diabetes, not simply as a treatment for severe obesity. At the same time, the trial was relatively small and had a short follow-up compared with major long-term bariatric studies, so its findings should be interpreted within the broader evidence base. For surgeons, procedure selection should remain individualized. Diabetes duration, endogenous insulin reserve, BMI, reflux, nutritional risk and patient preferences all influence the choice between procedures. The practical lesson is that sleeve gastrectomy and gastric bypass can have different metabolic profiles, and the patient's dominant clinical problem—not weight alone—should inform operative planning.
4 weeks back

Discover how catalytic nanozymes redefine autoimmune disease therapy by establishing a physiological redox set-point to restore immune tolerance without broad immunosuppression.
Last week

Recent research reveals that downregulating YAP1/TAZ-TEAD via Hippo signaling triggers spontaneous human trophoblast syncytialization in 3D cultures, illuminating placental biology and preeclampsia.
3 weeks back

A landmark comparative study evaluates atrial electrophysiology across humans, swine, and rodents. By linking cellular recordings with transcriptomics and in silico modeling, researchers resolve cross-species gaps, explaining translational failures to advance targeted therapies for atrial arrhythmias.
3 weeks back

A novel pathology-adaptive surface engineering strategy uses functionalized plasma polymer coatings to selectively modulate AGE adsorption, reducing oxidative stress and restoring bone formation in diabetic and aging microenvironments.
last month

Researchers have developed an innovative ultrasound-responsive nano-contrast agent that co-delivers CIITA-siRNA and rapamycin directly to inflamed thyroid tissue, significantly reducing autoimmune injury and thyroid autoantibodies in preclinical models of Hashimoto thyroiditis.
3 weeks back