.webp&w=384&q=75){kind=logo}
Loading, please wait...
Loading, please wait...
A Cochrane review comparing deep anterior lamellar keratoplasty (DALK) with penetrating keratoplasty (PK) for keratoconus found no clear difference in final visual acuity, keratometric astigmatism, or spherical equivalent across the small randomized evidence base available. The review did, however, find evidence that graft rejection was more likely after PK. DALK preserves the patient's own endothelium and therefore reduces exposure to endothelial rejection and chronic endothelial cell loss, but it is technically demanding and can be complicated by conversion to PK if the deep stromal plane cannot be reached safely. For corneal surgeons, this evidence supports the concept of matching the depth and location of disease to the least invasive effective graft. In a keratoconus eye with relatively healthy endothelium, DALK may offer meaningful biological advantages even when final visual acuity is similar. At the same time, surgeons must account for interface quality, intraoperative perforation, suturing requirements, and their own experience with big-bubble or other lamellar dissection techniques. The evidence remains limited enough that individualized case selection is essential.
Read summarized clinical updates, watch expert medical content, and earn CME certifications right from your smartphone.
Open your smartphone camera to scan and install.
A Cochrane review comparing deep anterior lamellar keratoplasty (DALK) with penetrating keratoplasty (PK) for keratoconus found no clear difference in final visual acuity, keratometric astigmatism, or spherical equivalent across the small randomized evidence base available. The review did, however, find evidence that graft rejection was more likely after PK. DALK preserves the patient's own endothelium and therefore reduces exposure to endothelial rejection and chronic endothelial cell loss, but it is technically demanding and can be complicated by conversion to PK if the deep stromal plane cannot be reached safely. For corneal surgeons, this evidence supports the concept of matching the depth and location of disease to the least invasive effective graft. In a keratoconus eye with relatively healthy endothelium, DALK may offer meaningful biological advantages even when final visual acuity is similar. At the same time, surgeons must account for interface quality, intraoperative perforation, suturing requirements, and their own experience with big-bubble or other lamellar dissection techniques. The evidence remains limited enough that individualized case selection is essential.
last month
Preclinical findings demonstrate that ginsenoside Ra1 preserves vascular integrity and attenuates multi-organ injury during sepsis by targeting non-muscle myosin heavy chain IIA (NMMHC IIA) and dampening TLR4/NF-κB/NLRP3 inflammatory signaling.
2 days back
An all-printed immunosensing microchip detects urinary sFlt-1 in just 10 minutes with 3.61 pg/mL sensitivity. By leveraging photonic bandgap engineering, this low-cost, cleanroom-free platform provides non-invasive preeclampsia screening, offering substantial benefits for point-of-care obstetric triage.
3 days back
Wearable ultrasound patches are transforming healthcare by shifting medicine from episodic evaluations to continuous monitoring. Discover how flexible acoustic transducers advance cardiovascular tracking, musculoskeletal imaging, neuromodulation, and on-demand closed-loop theranostics.
3 days back
A breakthrough study leverages natural language processing to accurately identify incident medication-related osteonecrosis of the jaw and track antiresorptive drug holidays from clinical narratives in electronic health records, advancing osteoporosis pharmacovigilance and dental safety.
Last week
Recent research defines ferro-aging as a conserved iron-lipid axis driving organ decline across primates. Age-related iron dyshomeostasis stimulates ACSL4-mediated lipid peroxidation, promoting cellular senescence. Notably, vitamin C directly inhibits ACSL4, suppressing phospholipid oxidation and multi-organ decay.
Last week
