.webp&w=384&q=75){kind=logo}
Loading, please wait...
Loading, please wait...
BLING III compared continuous with intermittent infusion of beta-lactam antibiotics in critically ill adults with sepsis. More than 7,000 patients were included in the primary analysis, receiving piperacillin-tazobactam or meropenem through one of the two dosing strategies. The primary endpoint was 90-day mortality. Continuous infusion produced a numerically lower mortality rate, but the difference did not reach conventional statistical significance. Clinical cure, however, was higher with continuous infusion. Why does this matter? Critically ill patients often have rapidly changing pharmacokinetics, altered volume of distribution and augmented or impaired renal clearance. Continuous infusion can improve the proportion of time that antibiotic concentrations remain above the pathogen's minimum inhibitory concentration, making it pharmacologically attractive. For HCPs, the practical message is that continuous beta-lactam infusion is a reasonable strategy to consider in selected critically ill patients, but it should not be promoted as a universal mortality-reducing intervention. Dose optimisation still depends on renal function, pathogen susceptibility, infection source and therapeutic drug-monitoring capability where available. The study directly supports CritiCARE's themes of antibiotic stewardship, sepsis management and pharmacotherapy in critical illness, particularly the programme's attention to antibiotic dosing and resistant infections.
Read summarized clinical updates, watch expert medical content, and earn CME certifications right from your smartphone.
Open your smartphone camera to scan and install.
BLING III compared continuous with intermittent infusion of beta-lactam antibiotics in critically ill adults with sepsis. More than 7,000 patients were included in the primary analysis, receiving piperacillin-tazobactam or meropenem through one of the two dosing strategies. The primary endpoint was 90-day mortality. Continuous infusion produced a numerically lower mortality rate, but the difference did not reach conventional statistical significance. Clinical cure, however, was higher with continuous infusion. Why does this matter? Critically ill patients often have rapidly changing pharmacokinetics, altered volume of distribution and augmented or impaired renal clearance. Continuous infusion can improve the proportion of time that antibiotic concentrations remain above the pathogen's minimum inhibitory concentration, making it pharmacologically attractive. For HCPs, the practical message is that continuous beta-lactam infusion is a reasonable strategy to consider in selected critically ill patients, but it should not be promoted as a universal mortality-reducing intervention. Dose optimisation still depends on renal function, pathogen susceptibility, infection source and therapeutic drug-monitoring capability where available. The study directly supports CritiCARE's themes of antibiotic stewardship, sepsis management and pharmacotherapy in critical illness, particularly the programme's attention to antibiotic dosing and resistant infections.
4 weeks back
A bioengineered oral nanozyme microsupplement converts pathological ROS into a protective polydopamine hydrogel shield. By curbing neutrophil extracellular traps and balancing T cells, this platform outperforms standard 5-ASA in preclinical colitis models, opening new paths for sustained remission.
3 days back
Recent research reveals that downregulating YAP1/TAZ-TEAD via Hippo signaling triggers spontaneous human trophoblast syncytialization in 3D cultures, illuminating placental biology and preeclampsia.
4 weeks back
Abdominal aortic aneurysm rupture remains a catastrophic vascular emergency. Groundbreaking research reveals that USP53 accelerates aneurysm progression by reprogramming smooth muscle cell metabolism toward aerobic glycolysis, highlighting a promising target beyond conventional diameter-based surveillance.
5 days back
A breakthrough study leverages natural language processing to accurately identify incident medication-related osteonecrosis of the jaw and track antiresorptive drug holidays from clinical narratives in electronic health records, advancing osteoporosis pharmacovigilance and dental safety.
4 days back
Recent research defines ferro-aging as a conserved iron-lipid axis driving organ decline across primates. Age-related iron dyshomeostasis stimulates ACSL4-mediated lipid peroxidation, promoting cellular senescence. Notably, vitamin C directly inhibits ACSL4, suppressing phospholipid oxidation and multi-organ decay.
5 days back
