Pancreatic ductal adenocarcinoma (PDAC) represents one of the most aggressive malignancies worldwide. Consequently, its five-year survival rate remains critically low. In addition, the rising global burden of pancreatitis further complicates the landscape of pancreatic health. Both conditions involve complex stromal alterations and pro-inflammatory microenvironments. Researchers are now investigating how Vitamin C pancreatic cells interactions might offer therapeutic benefits. This nutrient possesses unique dual properties, acting as an antioxidant in inflammatory states and a cytotoxic agent in cancer.

Potential Benefits for Vitamin C Pancreatic Cells

Vitamin C primarily targets oxidative stress and inflammatory pathways in pancreatitis tissue. However, in malignant settings, it can modulate signaling pathways relevant to tumor growth. Most existing research focuses on tumor cells alone. Consequently, we lack a clear understanding of its effects on the surrounding stromal and epithelial cells. This upcoming scoping review seeks to map these interactions across both benign and malignant diseases. Specifically, it will evaluate how high-dose vitamin C influences cell-to-cell communication within the pancreatic microenvironment.

Standardizing the Evidence Base

The review will follow the PRISMA-ScR guidelines to ensure methodological rigor. Furthermore, two independent reviewers will screen literature from databases like PubMed and Web of Science. They will focus on cellular-level effects, treatment durations, and various vitamin C isoforms. Therefore, the final results should provide a clear structure for future preclinical trials. By identifying knowledge gaps, this study could pave the way for more targeted therapeutic interventions.

Frequently Asked Questions

How does Vitamin C affect pancreatic cancer cells?

Vitamin C can act as a pro-oxidant at high concentrations, generating hydrogen peroxide that selectively targets and destroys malignant cells while sparing healthy tissue.

What are the primary goals of this scoping review?

The review aims to map existing literature on how Vitamin C influences the stromal and epithelial cells of the pancreas, highlighting research gaps in both cancer and inflammatory diseases.

Disclaimer: This content is for informational and educational purposes only. It does not constitute medical advice or a substitute for professional healthcare. Refer to the latest local and national guidelines for clinical practice.

References

Plischke H et al. The Influence of Vitamin C on Stromal and Epithelial Cells of the Pancreas in Malignant and Benign/Inflammatory Pancreatic Diseases: Protocol for a Scoping Review. JMIR Res Protoc. 2026 Jun 22. doi: 10.2196/91522. PMID: 42330555.

Bodeker KL et al. A randomized trial of pharmacological ascorbate, gemcitabine, and nab-paclitaxel for metastatic pancreatic cancer. Redox Biol. 2024:77(103375). doi: 10.1016/j.redox.2024.103375.

Alexander MS et al. Pharmacologic ascorbate reduces radiation-induced normal tissue toxicity and enhances tumor radiosensitization in pancreatic cancer. Cancer Res Commun. 2026. doi: 10.1158/2767-9764.CRC-26-0001.