Vaginal PRP Injection for Enhanced Sexual Function

Recent clinical findings highlight the potential of vaginal PRP injection as a therapeutic option for enhancing sexual health in women. Furthermore, a pilot randomized controlled trial (RCT) recently published in Obstetrics & Gynecology evaluated 52 premenopausal women. Specifically, researchers compared a one-time anterior vaginal wall injection of platelet-rich plasma (PRP) to a saline placebo.

Clinical Efficacy of Vaginal PRP Injection

Consequently, the study found that women treated with PRP experienced a significantly greater increase in their total Female Sexual Function Index (FSFI) scores. Moreover, at the six-week mark, the PRP group showed a median score change of 2.2 compared to only 0.3 in the control group. This improvement remained visible at the six-month follow-up. However, while subscale scores for desire, arousal, and lubrication improved, these specific changes did not reach statistical significance against the control. Additionally, nearly 70% of the PRP group reported overall improvement on the Patient Global Impression of Improvement (PGI-I) scale. Therefore, this suggests that the procedure is not only effective but also yields high patient satisfaction. Finally, clinicians reported no serious adverse events, confirming a favorable safety profile.

Frequently Asked Questions

How does a vaginal PRP injection improve sexual function?

Platelet-rich plasma contains concentrated growth factors that stimulate tissue regeneration, improve blood flow, and enhance nerve sensitivity in the vaginal wall.

Is the vaginal PRP injection procedure safe for women?

Yes, the latest clinical data indicates that the procedure is well-tolerated. In the randomized trial, participants reported no serious adverse events over a six-month period.

Disclaimer: This content is for informational and educational purposes only and does not constitute medical advice. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Refer to the latest local and national guidelines for clinical practice.

References

1. Clarke B et al. Vaginal Injection of Platelet-Rich Plasma for Sexual Function: A Randomized Controlled Trial. Obstet Gynecol. 2026 Mar 19. doi: 10.1097/AOG.0000000000006256. PMID: 41855531.

2. De Ponte A et al. Platelet-rich plasma in the management of vulvovaginal disorders: a systematic review. J Sex Med. 2026 Jan 5;23(1):qdaf307. doi: 10.1093/jsxmed/qdaf307. PMID: 41168677.