.webp&w=384&q=75){kind=logo}
Loading, please wait...
Loading, please wait...
Surface-enhanced Raman scattering (SERS) represents a powerful tool in modern diagnostics. However, standard signal tags often lack the sensitivity required for early biomolecule detection. Consequently, a new study introduces a highly sensitive SERS biosensing tumor markers platform. This platform integrates tyramine-mediated aggregation amplification (TMAA) with Au@Ag core-shell nanocubes.
Specifically, researchers functionalized tyramine and 4-mercaptobenzoic acid onto these nanocubes. In the presence of hydrogen peroxide, horseradish peroxidase catalyzes the deposition of these tags. This process triggers signal aggregation, which amplifies the Raman signal significantly. Furthermore, this method achieves a four-fold enhancement compared to conventional SERS tags.
The researchers coupled this TMAA strategy with encoded silica photonic crystal beads. This combination established a multiplex immunosensor capable of detecting alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA). The results demonstrated wide linear ranges and impressively low detection limits. Specifically, the limits reached 0.85 pg/mL for AFP and 0.12 pg/mL for CEA. Therefore, this technology offers a cost-effective platform for early cancer screening in clinical settings.
TMAA uses an enzymatic reaction to deposit tyramine-functionalized nanocubes onto labeled antibodies. This results in tag aggregation, which provides a significant boost to the Raman signal intensity compared to non-aggregated tags.
The proposed immunosensor achieved remarkably low detection limits of 0.85 pg/mL for alpha-fetoprotein (AFP) and 0.12 pg/mL for carcinoembryonic antigen (CEA), supporting early-stage diagnosis.
Multiplexing allows for the simultaneous detection of multiple biomarkers from a single sample. Consequently, this improves diagnostic accuracy and reduces the time and cost associated with cancer screening.
Disclaimer: This content is for informational and educational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Refer to the latest local and national guidelines for clinical practice.
References
Li J et al. Tyramine-mediated aggregation amplification of Au@Ag nanocubes Raman tags for sensitive multiplex SERS biosensing. Talanta. 2026 Jun 08. doi: undefined. PMID: 42258928.
Gkeka G, et al. SERS Immunosensors for Cancer Markers Detection. PMC. 2023. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214695/
Read summarized clinical updates, watch expert medical content, and earn CME certifications right from your smartphone.
Open your smartphone camera to scan and install.
Researchers develop a sensitive SERS immunosensor using Au@Ag nanocubes and TMAA for rapid, multiplex detection of tumor markers like AFP and CEA....
3 months ago
Explore the emerging role of Brixadi, an extended-release buprenorphine injection, for managing stimulant use disorder through kappa opioid receptor antagonism and steady plasma levels.
Today
A premature neonate developed upper limb compartment syndrome after uterine rupture extruded the arm through a scar defect. Conservative management with continuous monitoring yielded complete functional recovery and normal limb growth at 10-year follow-up, highlighting non-operative safety in selected cases.
Today
Dendritic cells bridge innate and adaptive immunity in myocardial infarction. This review explores their pathological roles, circulating dynamics, novel tolerogenic interventions, and how standard cardiovascular medications modulate dendritic cells to improve post-infarction myocardial repair and patient outcomes.
Today
Endoscopic posterior cervical fusion combines minimally invasive decompression, joint preparation, and rigid screw-rod fixation for atlantoaxial pathologies. Early clinical findings demonstrate solid bony union, excellent symptom relief, and minimal soft-tissue morbidity without significant vascular compromise.
Yesterday
Atherosclerosis involves extensive glycometabolic reprogramming across immune and vascular cells. This review examines how glycolysis, the pentose phosphate pathway, and lactate-driven epigenetic shifts fuel plaque vulnerability, while highlighting novel therapeutic targets like PFKFB3 and LDHA.
Today
