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This randomized study compared intravenous magnesium sulphate with saline in 74 craniotomy patients (37 per group). Magnesium was given as a 30-mg/kg bolus followed by 10 mg/kg/hour until dural closure. Pain scores were significantly lower at measured postoperative time points (P < 0.05). Mean rescue analgesic consumption over 24 hours was 32.43 ± 24 mg versus 79.7 ± 36 mg (P < 0.001), and first rescue analgesia was required later (2.03 vs 0.86 hours; P < 0.001). Conclusion: Magnesium may improve early postoperative pain control and reduce rescue-analgesic use, but the small study and limited follow-up constrain generalizability.
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This randomized study compared intravenous magnesium sulphate with saline in 74 craniotomy patients (37 per group). Magnesium was given as a 30-mg/kg bolus followed by 10 mg/kg/hour until dural closure. Pain scores were significantly lower at measured postoperative time points (P < 0.05). Mean rescue analgesic consumption over 24 hours was 32.43 ± 24 mg versus 79.7 ± 36 mg (P < 0.001), and first rescue analgesia was required later (2.03 vs 0.86 hours; P < 0.001). Conclusion: Magnesium may improve early postoperative pain control and reduce rescue-analgesic use, but the small study and limited follow-up constrain generalizability.
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