Scientists have successfully developed innovative NIR-II bioimaging carbon dots. These dots exhibit dual-phase photoluminescence in the second near-infrared window. Because this window spans 900 to 1700 nm, it allows for significantly deeper tissue penetration. Consequently, doctors can visualize biological structures with unprecedented clarity. The researchers employed a core-shell structure to induce a charge-transfer state. This design effectively boosts the fluorescence quantum yield to 5.91% at 920 nm.

Advancements in NIR-II Bioimaging Carbon Dots

The study highlights the potential for these dots in solid-state applications. Notably, the dots maintain a high quantum yield of 3.82% even in a solid film. Furthermore, the researchers tested the dots beneath porcine tissue. Specifically, the system identified a quick response code through 3 mm of tissue. This level of penetration is vital for surgical navigation and tumor detection. In addition, the dots offer a dual-phase emission mechanism. Therefore, they are ideal for multilevel information encryption. Such features provide a robust platform for both medical sensing and anti-counterfeiting.

How do NIR-II carbon dots improve medical imaging?

NIR-II carbon dots emit light at longer wavelengths. This reduces light scattering and background noise in tissues. Therefore, surgeons receive clearer images at greater depths compared to visible light probes.

What is the clinical significance of dual-phase photoluminescence?

Dual-phase photoluminescence allows the dots to function in both liquid and solid states. Consequently, they serve multiple roles, from injectable diagnostic agents to stable encryption films for secure patient records.

Disclaimer: This content is for informational and educational purposes only. It does not constitute professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Refer to the latest local and national guidelines for clinical practice.

References

Yu H et al. Customized NIR-II Dual-Phase Carbon Dots: Elucidating the Emission Mechanism for Smart Photonic Applications. Angew Chem Int Ed Engl. 2026 Apr 20. doi: 10.1002/anie.8078052. PMID: 42003413.

Zhu S, et al. Clinical Integration of NIR-II Fluorescence Imaging for Cancer Surgery: A Translational Evaluation of Preclinical and Intraoperative Systems. PMC. 2024.

Wang L, et al. Recent Progress on Second Near-Infrared Emitting Carbon Dots in Biomedicine. ACS Nano. 2024;18(18):11450-11475.