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Recent clinical evidence demonstrates that octacalcium phosphate granules and atelocollagen complex (OCP/Col) effectively achieve alveolar bone regeneration in patients with unilateral cleft lip and alveolus (CLA). Researchers monitored two pediatric cases where patients received OCP/Col grafting at age nine. Subsequently, they observed clear bone bridging between six months and three years post-surgery. Moreover, the integration of orthodontic edgewise treatment further enhanced the bone formation process. Consequently, these results indicate that the osteogenic induction phase can persist for several years, which is a vital factor for long-term clinical planning.
Orthodontic management plays a pivotal role in ensuring the success of alveolar bone regeneration when using OCP/Col composites. Because the material encourages natural osteogenic induction, it offers a robust alternative to traditional autologous bone grafting. Additionally, the long-term observation period revealed that bone growth continues even after the initial surgical phase. Therefore, dental specialists must consider this extended timeframe of osteogenesis when designing treatment protocols for cleft patients. Furthermore, this method significantly reduces the morbidity associated with harvesting bone from secondary donor sites.
OCP/Col is a biocompatible composite of octacalcium phosphate granules and atelocollagen. It acts as a scaffold that triggers natural bone formation in defects, eventually being replaced by the patient’s own bone tissue through a process of bio-resorption.
Yes, combining the grafting procedure with edgewise orthodontic treatment helps promote further bone formation and ensures the functional stability of the regenerated alveolar ridge over time.
Disclaimer: This content is for informational and educational purposes only and does not constitute medical advice. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition. Refer to the latest local and national guidelines for clinical practice.
References
Maeda-Iino A et al. Long-Term Clinical Results of Alveolar Bone Regeneration Using Octacalcium Phosphate Granules and Atelocollagen Complex Grafting in Alveolar Cleft. Cleft Palate Craniofac J. 2026 Jun 06. doi: 10.1177/10556656261455547. PMID: 42249746.
Kibe T, Maeda-Iino A, Takahashi T, Kamakura S, Suzuki O, Nakamura N. A Follow-Up Study on the Clinical Outcomes of Alveolar Reconstruction Using Octacalcium Phosphate Granules and Atelocollagen Complex. J Oral Maxillofac Surg. 2021 Dec;79(12):2462-2471. doi: 10.1016/j.joms.2021.09.017.
Kawai T, Kamakura S. First clinical application of octacalcium phosphate collagen composite in human bone defect. Tissue Eng Part A. 2014;20(9-10):1336-1341. doi: 10.1089/ten.tea.2013.0508.
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Recent findings highlight how OCP/Col grafting promotes sustained alveolar bone regeneration in cleft lip and alveolus patients over several years....
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