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The GENIE systematic review and meta-analysis pooled 86 population-based studies from 30 countries to estimate the incidence of neonatal and infantile-onset epilepsies and epilepsy syndromes. The cumulative incidence of epilepsy in the first 2 years of life was 236.0 per 100,000 live births (95% CI 164.7–338.2). Developmental and epileptic encephalopathies (DEEs) were the most frequent group at 67.7 per 100,000 (95% CI 42.1–108.9), with infantile epileptic spasms syndrome the most common DEE at 31.6 per 100,000 (95% CI 27.5–36.2). Self-limited infantile epilepsy was the most frequent self-limited syndrome (13.0 per 100,000; 95% CI 9.2–18.2). Between-study heterogeneity was high and prediction intervals were wide; most data came from high-income European countries, with no data from the African or Eastern Mediterranean regions. The authors advise that the estimates be read as broad indicators and call for population-based studies in under-represented regions.
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The GENIE systematic review and meta-analysis pooled 86 population-based studies from 30 countries to estimate the incidence of neonatal and infantile-onset epilepsies and epilepsy syndromes. The cumulative incidence of epilepsy in the first 2 years of life was 236.0 per 100,000 live births (95% CI 164.7–338.2). Developmental and epileptic encephalopathies (DEEs) were the most frequent group at 67.7 per 100,000 (95% CI 42.1–108.9), with infantile epileptic spasms syndrome the most common DEE at 31.6 per 100,000 (95% CI 27.5–36.2). Self-limited infantile epilepsy was the most frequent self-limited syndrome (13.0 per 100,000; 95% CI 9.2–18.2). Between-study heterogeneity was high and prediction intervals were wide; most data came from high-income European countries, with no data from the African or Eastern Mediterranean regions. The authors advise that the estimates be read as broad indicators and call for population-based studies in under-represented regions.
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