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Researchers examined 7,849 adults with cardiovascular-kidney-metabolism (CKM) syndrome and found a U-shaped relationship between estimated glucose disposal rate (eGDR) and cardiovascular disease (CVD) risk. Below 11.82 mg/kg/min, higher eGDR decreased CVD risk. Above this point, higher eGDR increased CVD risk. They concluded that both low and high eGDR were associated with elevated CVD risk in CKM syndrome.

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Researchers examined 7,849 adults with cardiovascular-kidney-metabolism (CKM) syndrome and found a U-shaped relationship between estimated glucose disposal rate (eGDR) and cardiovascular disease (CVD) risk. Below 11.82 mg/kg/min, higher eGDR decreased CVD risk. Above this point, higher eGDR increased CVD risk. They concluded that both low and high eGDR were associated with elevated CVD risk in CKM syndrome.
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