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This systematic review and meta-analysis evaluated the diagnostic accuracy of MRI performed within 10 days after transsphenoidal resection of pituitary adenoma. Seven studies including 449 patients were pooled using a bivariate random-effects model. For detecting residual tumour, immediate postoperative MRI showed a pooled sensitivity of 93.4% (95% CI 85.9–97.1%) and specificity of 95.0% (95% CI 87.1–98.2%), with a positive likelihood ratio of 18.73 and a negative likelihood ratio of 0.07; the diagnostic odds ratio estimate was highly imprecise. The authors conclude that early postoperative MRI has excellent diagnostic performance for residual tumour, but note that little evidence exists on whether it changes decisions about immediate re-operation or influences long-term remission.
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This systematic review and meta-analysis evaluated the diagnostic accuracy of MRI performed within 10 days after transsphenoidal resection of pituitary adenoma. Seven studies including 449 patients were pooled using a bivariate random-effects model. For detecting residual tumour, immediate postoperative MRI showed a pooled sensitivity of 93.4% (95% CI 85.9–97.1%) and specificity of 95.0% (95% CI 87.1–98.2%), with a positive likelihood ratio of 18.73 and a negative likelihood ratio of 0.07; the diagnostic odds ratio estimate was highly imprecise. The authors conclude that early postoperative MRI has excellent diagnostic performance for residual tumour, but note that little evidence exists on whether it changes decisions about immediate re-operation or influences long-term remission.
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