.webp&w=384&q=75){kind=logo}
Loading, please wait...
Loading, please wait...
Researchers have successfully completed the first in vivo pharmacokinetic evaluation of 3D-printed veterinary formulations, specifically targeting canine heart failure management. This clinical trial utilized semisolid extrusion (SSE) to create 2.5 mg pimobendan (PBD) tablets, referred to as 'printlets.' These custom-made dosages offer a potential solution to the limitations of mass-produced veterinary medications. Frequently, commercial formulations lack dose flexibility and present sizing issues that complicate long-term treatment for smaller patients.
The study compared these innovative printlets against the established commercial formulation, Vetmedin, in healthy Beagle dogs. Scientists analyzed both formulations for weight, drug content, and in vitro dissolution before oral administration. To ensure accuracy, the team quantified plasma PBD concentrations using LC-MS/MS and determined pharmacokinetic parameters through non-compartmental analysis. While both formulations were safely tolerated without adverse effects, the 3D-printed veterinary formulations exhibited a distinct sustained release profile. This variation in absorption underscores the ability of digital manufacturing to modulate how a patient processes medication.
Digital manufacturing provides several advantages for modern veterinary practice. Firstly, SSE 3D printing allows for precise dosing, which is vital for managing chronic conditions like heart failure where titration is key. Secondly, the technology enables the creation of chewable, palatable tablets that can improve patient adherence. Furthermore, the ability to print medications on-demand helps clinicians adapt therapy to the evolving physiological needs of the patient. Consequently, this study serves as a critical proof-of-concept for the wider adoption of 3D printing in pharmacy settings.
Semisolid extrusion is a specialized 3D printing technique that uses medicinal gels or pastes to construct dosage forms layer-by-layer. Because it operates at lower temperatures, it is highly suitable for drugs that are sensitive to heat.
Unlike traditional mass-produced tablets, 3D-printed versions allow for highly customizable dosages and varied release profiles. This flexibility is essential for personalized medicine, especially when standard tablet sizes do not meet a specific patient's weight or metabolic requirements.
Disclaimer: This content is for informational and educational purposes only. It does not constitute professional medical or veterinary advice. Refer to the latest local and national guidelines for clinical practice.
References
Leão J et al. From prototype to veterinary patient: a pharmacokinetic clinical trial of 3D-printed pimobendan tablets in beagle dogs. Drug Deliv Transl Res. 2026 May 25. doi: 10.1007/s13346-026-02156-z. PMID: 42184094.
Zhang B, et al. An investigation into the effects of ink formulations of semi-solid extrusion 3D printing on the performance of printed solid dosage forms. RSC Pharmaceutics. 2023.
CurifyLabs. A new technology brings 3D-printed compounded medications to the veterinary space. dvm360. 2025.
Read summarized clinical updates, watch expert medical content, and earn CME certifications right from your smartphone.
Open your smartphone camera to scan and install.
A pioneering study in Beagle dogs evaluates 3D-printed pimobendan tablets, demonstrating the potential for personalized drug delivery in veterinary medicine...
2 months ago
Andhra Pradesh reported 10 new Covid-19 cases, taking the state tally to 49 while deaths remain at four. With 24 patients hospitalized and 16 under home isolation, the Health Department has intensified monitoring. Medical professionals should review regional distribution, diagnostic protocols, and management plans.
Today
An 11-year Swedish registry study of 618 uterine sarcoma patients found that minimally invasive surgery yielded survival comparable to open surgery in early stages. However, adjuvant chemotherapy conferred no survival benefit in localized or advanced disease, highlighting stage and histology as key outcomes.
3 days back
A cross-sectional study evaluates post-intensive care syndrome in cardiac patients 2-4 weeks post-ICU discharge, highlighting cognitive, psychological, and functional impairments and the need for structured multidisciplinary rehabilitation.
3 days back
Anterior cruciate ligament reconstruction failure lacks uniform definition. A narrative review proposes an integrative framework incorporating objective and subjective instability, persistent pain, restricted motion, graft rupture, and secondary meniscal injury to standardize clinical reporting.
3 days back
With World Obesity Atlas data warning that over 41 million Indian children are overweight or obese, ICMR and NIN have unveiled a 10-point policy roadmap. The initiative calls for mandatory front-of-pack labeling, HFSS taxes, strict marketing bans, and healthier school environments to curb non-communicable diseases.
Today
