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Experts compared 15 cutaneous neurofibromas (cNFs) and adjacent skin from NF1 patients. Despite high overall similarity, cNFs exhibited reduced expression of proteins linked to proliferation, metabolism, angiogenesis, and extracellular matrix remodeling, highlighting their quiescent nature. These findings underscore the challenge of developing cNF-specific treatments due to their close molecular resemblance to normal skin.
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Experts compared 15 cutaneous neurofibromas (cNFs) and adjacent skin from NF1 patients. Despite high overall similarity, cNFs exhibited reduced expression of proteins linked to proliferation, metabolism, angiogenesis, and extracellular matrix remodeling, highlighting their quiescent nature. These findings underscore the challenge of developing cNF-specific treatments due to their close molecular resemblance to normal skin.
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