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A randomized, double-blind, placebo-controlled trial evaluated whether adding pregabalin to dexamethasone-based multimodal analgesia could improve postoperative pain control in 800 adults undergoing elective 2–3-level lumbar laminectomy. Patients received either 8 or 4 mg intravenous dexamethasone, with or without 150 mg oral pregabalin. The combination of 8 mg dexamethasone plus pregabalin produced the lowest postoperative pain scores and the lowest 24-hour opioid consumption. A significant interaction was also observed between the higher dexamethasone dose and pregabalin. Sedation and dizziness were more frequent in the pregabalin groups (20–22.5% vs 5% with placebo), although there were no significant differences in surgical-site infection or hyperglycemia. The authors concluded that preemptive pregabalin combined with 8 mg dexamethasone may be a useful multimodal analgesic strategy following spinal surgery, while noting the need for further studies to confirm generalizability.
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A randomized, double-blind, placebo-controlled trial evaluated whether adding pregabalin to dexamethasone-based multimodal analgesia could improve postoperative pain control in 800 adults undergoing elective 2–3-level lumbar laminectomy. Patients received either 8 or 4 mg intravenous dexamethasone, with or without 150 mg oral pregabalin. The combination of 8 mg dexamethasone plus pregabalin produced the lowest postoperative pain scores and the lowest 24-hour opioid consumption. A significant interaction was also observed between the higher dexamethasone dose and pregabalin. Sedation and dizziness were more frequent in the pregabalin groups (20–22.5% vs 5% with placebo), although there were no significant differences in surgical-site infection or hyperglycemia. The authors concluded that preemptive pregabalin combined with 8 mg dexamethasone may be a useful multimodal analgesic strategy following spinal surgery, while noting the need for further studies to confirm generalizability.
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