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Researchers investigated PLCH1 in breast cancer across 40,442 tumor and 15,648 normal samples. PLCH1 was overexpressed in breast cancer, correlating with worse prognosis and ER, PR, and HER2 status. Experimental validation showed PLCH1 knockdown significantly inhibited breast cancer cell proliferation by inducing cell cycle arrest and downregulating CDK1. Mechanistically, PLCH1 silencing suppressed the ERK1/2-EGR1 pathway.
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Researchers investigated PLCH1 in breast cancer across 40,442 tumor and 15,648 normal samples. PLCH1 was overexpressed in breast cancer, correlating with worse prognosis and ER, PR, and HER2 status. Experimental validation showed PLCH1 knockdown significantly inhibited breast cancer cell proliferation by inducing cell cycle arrest and downregulating CDK1. Mechanistically, PLCH1 silencing suppressed the ERK1/2-EGR1 pathway.
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