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This double-blind, randomized, placebo-controlled trial assessed the effects of perioperative pregabalin on postoperative pain following laminectomy and instrumented fusion for degenerative lumbar spine disease. Fifty-four patients were randomized to receive 150 mg pregabalin, 300 mg pregabalin, or placebo before and after surgery. There was no significant difference in cumulative 48-hour morphine consumption among the groups. However, postoperative pain at 24 hours was significantly lower in both pregabalin groups compared with placebo: mean pain scores were 1.1 with 150 mg, 1.4 with 300 mg, and 3.1 with placebo (P=0.007). No significant differences were observed in opioid-related adverse effects. The study therefore suggests that perioperative pregabalin may provide an early postoperative analgesic benefit, although it did not reduce overall opioid consumption.
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This double-blind, randomized, placebo-controlled trial assessed the effects of perioperative pregabalin on postoperative pain following laminectomy and instrumented fusion for degenerative lumbar spine disease. Fifty-four patients were randomized to receive 150 mg pregabalin, 300 mg pregabalin, or placebo before and after surgery. There was no significant difference in cumulative 48-hour morphine consumption among the groups. However, postoperative pain at 24 hours was significantly lower in both pregabalin groups compared with placebo: mean pain scores were 1.1 with 150 mg, 1.4 with 300 mg, and 3.1 with placebo (P=0.007). No significant differences were observed in opioid-related adverse effects. The study therefore suggests that perioperative pregabalin may provide an early postoperative analgesic benefit, although it did not reduce overall opioid consumption.
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