.webp&w=384&q=75){kind=logo}
Loading, please wait...
Loading, please wait...
This multicenter study developed and externally validated a machine-learning model to estimate individualized benefit from cranial surgery in severe TBI. Among 10,782 TQIP patients, 23% underwent surgery. The model showed strong discrimination for favorable discharge (AUC 0.845) and mortality (AUC 0.890). Simulated use increased favorable discharge by 4.1% and reduced mortality by 13.1%. In 182 external-validation patients, improvements were 10.6% and 43.4%, respectively.
Read summarized clinical updates, watch expert medical content, and earn CME certifications right from your smartphone.
Open your smartphone camera to scan and install.
This multicenter study developed and externally validated a machine-learning model to estimate individualized benefit from cranial surgery in severe TBI. Among 10,782 TQIP patients, 23% underwent surgery. The model showed strong discrimination for favorable discharge (AUC 0.845) and mortality (AUC 0.890). Simulated use increased favorable discharge by 4.1% and reduced mortality by 13.1%. In 182 external-validation patients, improvements were 10.6% and 43.4%, respectively.
Today
A randomized trial shows oral DL-3-n-butylphthalide (200 mg thrice daily) significantly slows functional decline in spinocerebellar ataxia type 3 over 12 months, improving SARA and SCAFI scores with favorable safety and zero serious adverse events.
2 days back
Recent research reveals that downregulating YAP1/TAZ-TEAD via Hippo signaling triggers spontaneous human trophoblast syncytialization in 3D cultures, illuminating placental biology and preeclampsia.
Last week
A landmark comparative study evaluates atrial electrophysiology across humans, swine, and rodents. By linking cellular recordings with transcriptomics and in silico modeling, researchers resolve cross-species gaps, explaining translational failures to advance targeted therapies for atrial arrhythmias.
Last week
A novel pathology-adaptive surface engineering strategy uses functionalized plasma polymer coatings to selectively modulate AGE adsorption, reducing oxidative stress and restoring bone formation in diabetic and aging microenvironments.
last month
Researchers have developed an innovative ultrasound-responsive nano-contrast agent that co-delivers CIITA-siRNA and rapamycin directly to inflamed thyroid tissue, significantly reducing autoimmune injury and thyroid autoantibodies in preclinical models of Hashimoto thyroiditis.
Last week
