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This randomized double-blind trial compared lacosamide with propranolol for episodic migraine prevention. A total of 574 patients completed treatment. Lacosamide 50 mg twice daily produced reductions in monthly migraine days, migraine days requiring acute medication and HIT-6 scores comparable to propranolol 80 mg twice daily. Between-group differences were not significant for monthly migraine days (P=0.13), ≥50% responder rate (P=0.22), acute-medication migraine days (P=0.57) or HIT-6 (P=0.61). Lacosamide was well tolerated.
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This randomized double-blind trial compared lacosamide with propranolol for episodic migraine prevention. A total of 574 patients completed treatment. Lacosamide 50 mg twice daily produced reductions in monthly migraine days, migraine days requiring acute medication and HIT-6 scores comparable to propranolol 80 mg twice daily. Between-group differences were not significant for monthly migraine days (P=0.13), ≥50% responder rate (P=0.22), acute-medication migraine days (P=0.57) or HIT-6 (P=0.61). Lacosamide was well tolerated.
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