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This retrospective study evaluated 43 patients with drug-resistant epilepsy undergoing resective surgery using quantitative dual-tracer PET (^18F-FDG and ^18F-FMZ) integrated with ictal SEEG. The FDG-FMZ overlap region was significantly associated with Engel class I outcomes (P=.018), while its concordance with SEEG (P=.017) and resection coverage (P=.016) predicted favorable outcomes. The fusion model achieved an AUC of 0.902, with 87.4% specificity at 80% sensitivity.
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This retrospective study evaluated 43 patients with drug-resistant epilepsy undergoing resective surgery using quantitative dual-tracer PET (^18F-FDG and ^18F-FMZ) integrated with ictal SEEG. The FDG-FMZ overlap region was significantly associated with Engel class I outcomes (P=.018), while its concordance with SEEG (P=.017) and resection coverage (P=.016) predicted favorable outcomes. The fusion model achieved an AUC of 0.902, with 87.4% specificity at 80% sensitivity.
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