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This systematic review analyzed 87 studies on biomarkers in human angiosarcoma (AS), a rare vascular malignancy with poor prognosis. Key findings include recurrent mutations (TP53, POT1, MYC), disrupted signaling pathways (VEGF, PI3K/Akt/mTOR), and diagnostic protein markers (CD31, ERG). These molecular insights highlight potential avenues for improving AS diagnosis, prognosis, and targeted therapies.
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This systematic review analyzed 87 studies on biomarkers in human angiosarcoma (AS), a rare vascular malignancy with poor prognosis. Key findings include recurrent mutations (TP53, POT1, MYC), disrupted signaling pathways (VEGF, PI3K/Akt/mTOR), and diagnostic protein markers (CD31, ERG). These molecular insights highlight potential avenues for improving AS diagnosis, prognosis, and targeted therapies.
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