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Spinal cord injury (SCI) typically leads to profound muscle atrophy, aerobic deconditioning, and metabolic dysfunction. While standard exercise interventions provide some benefit, their effects are often modest. Consequently, researchers have looked for ways to amplify the body\'s physiological response to physical activity. A recent randomized controlled trial explored whether testosterone augmented exercise SCI protocols could safely improve outcomes for this population.
The study results demonstrated a significant advantage for the multimodality intervention. Participants who received intramuscular testosterone undecanoate alongside functional electrical stimulation-assisted leg cycling (FES-LC) and arm ergometry (AE) gained substantially more lean mass. Specifically, the multimodality group showed a whole-body lean mass increase of 1.84 kg. Moreover, they gained 0.92 kg of lean mass in the lower extremities, which is a critical area often resistant to traditional rehabilitation. These findings suggest that testosterone plays a vital role in counteracting the muscle wasting associated with chronic SCI.
In addition to muscle gains, the testosterone-augmented group experienced significant improvements in blood markers. The intervention corrected anemia in a higher proportion of participants compared to the placebo group. While between-group differences in aerobic capacity (peak VO2) did not reach statistical significance, the multimodality group showed a notable 19% within-group improvement. Furthermore, this dual approach proved safe, as adverse event rates were similar across both study arms. Therefore, combining hormonal therapy with multimodal exercise could offer a more comprehensive strategy for improving the health of individuals living with SCI.
Testosterone provides anabolic support that enhances muscle protein synthesis. When combined with exercise, it helps increase lean body mass and improves hemoglobin levels, which can assist in correcting anemia and potentially boosting energy levels.
Yes, this trial reported that the home-based multimodality intervention was safe. Adverse event rates were comparable between the group receiving testosterone and the group receiving a placebo, indicating good tolerability.
The study observed a 19% within-group increase in aerobic capacity (peak VO2) for those using testosterone and exercise. Although the difference between the treatment and control groups was not statistically significant, the individual improvements within the treated group were clinically relevant.
Disclaimer: This content is for informational and educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Refer to the latest local and national guidelines for clinical practice.
References
Reid KF et al. Effects of Testosterone-Augmented Multimodal Exercise Intervention in Spinal Cord Injury: A Randomized Controlled Trial. J Clin Endocrinol Metab. 2026 Apr 16. doi: undefined. PMID: 41988780.
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A randomized trial shows that adding testosterone to multimodal exercise significantly improves lean mass and hemoglobin in adults with spinal cord injury....
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