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This meta-analysis of 29 studies, comprising 5765 women with polycystic ovary syndrome (PCOS), found a 19.7% prevalence of subclinical hypothyroidism (SCH). PCOS patients with SCH had significantly higher HOMA-IR and fasting insulin levels. Thyroid stimulating hormone (TSH) cut-off variability impacts prevalence. SCH worsens insulin resistance, but the clinical significance of these metabolic changes and long-term risks require further study.

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This meta-analysis of 29 studies, comprising 5765 women with polycystic ovary syndrome (PCOS), found a 19.7% prevalence of subclinical hypothyroidism (SCH). PCOS patients with SCH had significantly higher HOMA-IR and fasting insulin levels. Thyroid stimulating hormone (TSH) cut-off variability impacts prevalence. SCH worsens insulin resistance, but the clinical significance of these metabolic changes and long-term risks require further study.
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