.webp&w=384&q=75){kind=logo}
Loading, please wait...
Loading, please wait...
This economic evaluation of the randomized Cervical Spondylotic Myelopathy Surgical (CSM-S) trial compared the cost-effectiveness of anterior cervical discectomy/fusion (ACDF), posterior cervical decompression/fusion (PCDF) and laminoplasty (LP) from a societal perspective over 1 year. Of 163 enrolled patients, 153 US patients were analysed as treated (ACDF 61, PCDF 64, LP 28). Mean total costs were highest after PCDF ($62,383) compared with ACDF ($53,074) and LP ($47,426; P=0.017). LP produced the greatest QALY gains (0.792 vs 0.732 for ACDF, P=0.08; vs 0.698 for PCDF, P=0.01). At a willingness-to-pay threshold of $150,000 per QALY gained, the probability that LP was cost-effective was 99.7% versus PCDF and 96% versus ACDF. The authors conclude that LP yielded greater 1-year quality-of-life improvements at lower cost.
Read summarized clinical updates, watch expert medical content, and earn CME certifications right from your smartphone.
Open your smartphone camera to scan and install.
This economic evaluation of the randomized Cervical Spondylotic Myelopathy Surgical (CSM-S) trial compared the cost-effectiveness of anterior cervical discectomy/fusion (ACDF), posterior cervical decompression/fusion (PCDF) and laminoplasty (LP) from a societal perspective over 1 year. Of 163 enrolled patients, 153 US patients were analysed as treated (ACDF 61, PCDF 64, LP 28). Mean total costs were highest after PCDF ($62,383) compared with ACDF ($53,074) and LP ($47,426; P=0.017). LP produced the greatest QALY gains (0.792 vs 0.732 for ACDF, P=0.08; vs 0.698 for PCDF, P=0.01). At a willingness-to-pay threshold of $150,000 per QALY gained, the probability that LP was cost-effective was 99.7% versus PCDF and 96% versus ACDF. The authors conclude that LP yielded greater 1-year quality-of-life improvements at lower cost.
Today
A multicenter study validates a machine learning-guided recalibrated SOFA score, demonstrating significantly improved ICU mortality discrimination while preserving the simple, additive, point-based structure critical for bedside decision-making.
Today
A landmark study reveals that lipid-rich malignant ascites alters the T-cell metabolic transcriptome, causing cholesterol efflux and impaired fatty acid oxidation. This suppresses TCR signalling and blocks BiTE immunotherapy, while lipid depletion restores antitumour cytotoxicity in ovarian cancer.
Today
A registry study of 4,989 patients evaluates transvenous lead extraction for right-sided cardiac devices. Despite longer dwell times and older leads, right-sided extractions achieve high procedural success and comparable safety to left-sided approaches.
Today
Recent crash analyses demonstrate significant variations in traffic injury severity across vehicle seating positions. Electric vehicle passengers face disproportionately higher trauma risks than drivers, particularly during airbag deployments, demanding adapted emergency assessment and clinical vigilance.
Today
Understand the causal role of Lipoprotein(a) in cardiovascular disease, why international guidelines recommend once-in-a-lifetime molar testing, and the clinical implications of recent phase 3 RNA outcome trials.
Today
