Scientists are revolutionizing bioactive peptide delivery through sophisticated nanotechnology. However, traditional oral applications often fail because of low gastrointestinal stability. Consequently, enzymes in the digestive tract degrade these beneficial molecules before they reach their target. Therefore, researchers developed a novel hybrid system using liposome-loaded electrospun fibers to safeguard these compounds.

Advancing Bioactive Peptide Delivery with Nanotechnology

Specifically, the study team encapsulated glutenin hydrolysate (GH) into lecithin-phytosterol liposomes with an average size of 76 nm. Furthermore, they successfully embedded these liposomes into pullulan and carboxymethylcellulose nanofibers. Moreover, the results demonstrated that this hybrid configuration significantly protected the GH during the harsh gastric phase. Additionally, the system preserved the antioxidant activity of the GH throughout the digestive process. Notably, co-axial fibers provided a more sustained intestinal release compared to uni-axial or free-GH fibers. Similarly, the incorporation of liposomes into the fiber matrix improved mucoadhesive properties. Thus, this food-grade strategy offers a promising solution for the oral delivery of bioactive peptides in functional foods.

Frequently Asked Questions

Why is bioactive peptide delivery via the oral route challenging?

Oral delivery faces hurdles like enzymatic degradation and low gastrointestinal stability, which reduce the absorption of health-promoting peptides. However, advanced encapsulation techniques can mitigate these risks effectively.

How do co-axial fibers improve peptide release?

Co-axial fibers provide a core-sheath structure that allows for more sustained intestinal release. Consequently, they protect the bioactive load more effectively than conventional uni-axial fibers during gastric transit.

Disclaimer: This content is for informational and educational purposes only. It does not constitute medical advice, diagnosis, or treatment. Refer to the latest local and national guidelines for clinical practice.

References

1. Kalintas Caglar N et al. Characterization, in vitro release, and antioxidant activity of glutenin hydrolysate encapsulated in liposome-loaded uni-axial and co-axial electrospun fibers. J Sci Food Agric. 2026 Mar 11. doi: 10.1002/jsfa.70570. PMID: 41813609.
2. McClements DJ. Advancing oral delivery of bioactive peptides using colloidal delivery systems. Food Research International. 2018;108:320-334.
3. Zhang L, et al. Electrospun nanofibers for the delivery of bioactive agents. Advanced Drug Delivery Reviews. 2022;185:114302.