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This cohort study used data from the population-based Mayo Clinic Study of Aging to examine whether delirium during hospitalization predicts later cognitive decline in adults who were cognitively unimpaired at baseline. Among 3,501 participants with at least one hospitalization (median age 74.1 years), delirium was identified using a validated natural language processing algorithm applied to clinical notes. Over a median follow-up of 7.2 years, 75 participants (2.1%) had delirium documented within 30 days of a hospitalization. After adjustment for age, sex, education and APOE ε4 status, delirium was associated with a higher risk of incident mild cognitive impairment (aHR 3.67, 95% CI 2.19–6.15) and dementia (aHR 5.39, 95% CI 2.94–9.85), as well as accelerated decline on serial cognitive testing. As an observational study, it demonstrates association rather than causation, but it highlights delirium as a marker of long-term cognitive risk.
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This cohort study used data from the population-based Mayo Clinic Study of Aging to examine whether delirium during hospitalization predicts later cognitive decline in adults who were cognitively unimpaired at baseline. Among 3,501 participants with at least one hospitalization (median age 74.1 years), delirium was identified using a validated natural language processing algorithm applied to clinical notes. Over a median follow-up of 7.2 years, 75 participants (2.1%) had delirium documented within 30 days of a hospitalization. After adjustment for age, sex, education and APOE ε4 status, delirium was associated with a higher risk of incident mild cognitive impairment (aHR 3.67, 95% CI 2.19–6.15) and dementia (aHR 5.39, 95% CI 2.94–9.85), as well as accelerated decline on serial cognitive testing. As an observational study, it demonstrates association rather than causation, but it highlights delirium as a marker of long-term cognitive risk.
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