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This meta-analysis of 15 studies evaluated neoadjuvant endocrine therapy (NET), chemotherapy (NCT), and chemo-endocrine therapy (NCET) in ER-positive breast cancer. NET showed higher clinical and complete response rates than NCT but no advantage in pathological complete response or breast-conserving surgery. NCET offered no additional benefit over NET or NCT. Both NET and NCT remain valid options, but clearer decision-making criteria are needed.

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This meta-analysis of 15 studies evaluated neoadjuvant endocrine therapy (NET), chemotherapy (NCT), and chemo-endocrine therapy (NCET) in ER-positive breast cancer. NET showed higher clinical and complete response rates than NCT but no advantage in pathological complete response or breast-conserving surgery. NCET offered no additional benefit over NET or NCT. Both NET and NCT remain valid options, but clearer decision-making criteria are needed.
2 months ago

A retrospective cohort study of 7,716 ICU patients from the MIMIC-IV database demonstrates that Gradient Boosting Decision Trees significantly outperform traditional SOFA scores in predicting in-hospital mortality among patients with sepsis and diabetes, with SHAP analysis providing clinical interpretability.
Today

A prenatal case highlights severe glutaric acidemia type II presenting as bilateral hyperechoic cystic kidneys at 18 weeks. Whole-exome sequencing revealed a novel homozygous ETFDH frameshift variant, demonstrating the power of rapid genetic testing in fetal renal anomalies.
Today

This article reviews the forensic and clinical complexities of acute myocarditis arising on left ventricular hypertrophy in children, highlighting early diagnostic red flags and multidisciplinary postmortem autopsy protocols.
Today

This comparative study evaluates posterior labral tears with and without glenohumeral instability, highlighting distinct demographic patterns, MRI underestimation in stable shoulders, and successful arthroscopic repair outcomes.
Yesterday

A clinical study demonstrates that early intervention with tocilizumab, either as monotherapy or bridged with corticosteroids, achieves significant proptosis reduction and resolves active inflammation in treatment-naive thyroid eye disease.
Yesterday