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This study examined whether cognitive enhancement therapy (CET), an 18-month cognitive remediation intervention, could protect against temporolimbic gray matter loss in early-course schizophrenia. A total of 99 participants underwent MRI, cognitive, and social adjustment assessments at baseline, 9 months, and 18 months; 56 received CET and 43 received enriched supportive therapy. The right rostral anterior cingulate was the only primary brain region showing a significant group-by-time interaction, but this change was not associated with improvements in cognition or social adjustment. No significant differential treatment effects were observed in the secondary brain regions. The study therefore did not reproduce the previously reported broad neuroprotective effects of CET on gray matter volume, highlighting the need for further research into the neurobiological mechanisms underlying cognitive remediation in schizophrenia.
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This study examined whether cognitive enhancement therapy (CET), an 18-month cognitive remediation intervention, could protect against temporolimbic gray matter loss in early-course schizophrenia. A total of 99 participants underwent MRI, cognitive, and social adjustment assessments at baseline, 9 months, and 18 months; 56 received CET and 43 received enriched supportive therapy. The right rostral anterior cingulate was the only primary brain region showing a significant group-by-time interaction, but this change was not associated with improvements in cognition or social adjustment. No significant differential treatment effects were observed in the secondary brain regions. The study therefore did not reproduce the previously reported broad neuroprotective effects of CET on gray matter volume, highlighting the need for further research into the neurobiological mechanisms underlying cognitive remediation in schizophrenia.
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