.webp&w=384&q=75){kind=logo}
Loading, please wait...
Loading, please wait...
Biological sulfur species have emerged as versatile mediators of redox chemistry. Consequently, they link thiol-based signaling and oxidative stress response to metabolic regulation. Among these species, biological metal persulfides (RSSH) occupy a unique chemical niche. Furthermore, these molecules exhibit both nucleophilic and electrophilic reactivity. Because of their tunable acidity, they allow for dynamic sulfur exchange. As a result, persulfides act as central participants in cellular homeostasis. Similarly, they facilitate sulfur trafficking processes within the cell.
Specifically, recent advances show how coordination modes modulate reactivity. For example, the local microenvironment and metal identity play critical roles. Therefore, metal-bound persulfides can facilitate the biosynthesis of cofactors. In addition, these cofactors remain essential for various enzymatic activities in human physiology. However, researchers are also exploring related selenium systems. While selenium and sulfur are similar, they showcase distinct differences. Moreover, these emerging insights clarify how persulfides regulate signaling. Consequently, doctors can now better understand metabolic disorders related to sulfur. Thus, this knowledge provides a bridge from chemistry to clinical function. In conclusion, sulfur biology remains a vital field for future therapeutic development.
They are specialized sulfur species (RSSH) bound to metal centers that facilitate redox signaling and cofactor biosynthesis within cells.
Persulfides regulate oxidative signaling and protect cells against stress, which is critical for maintaining metabolic and cardiovascular health.
Persulfides exhibit higher nucleophilicity and unique electrophilic character, making them more reactive and versatile than traditional thiols like glutathione.
Disclaimer: This content is for informational and educational purposes only. It does not constitute medical advice or a professional relationship. Refer to the latest local and national guidelines for clinical practice.
References
1. Li K et al. From Fundamental Chemistry to Biological Function: The Biological and Abiological Chemistry of Metal Persulfides and Related Species. Chem Rev. 2026 May 27. doi: 10.1021/acs.chemrev.5c00935. PMID: 42201751.
2. Cuevasanta E et al. Hydrogen Sulfide and Persulfides Oxidation by Biologically Relevant Oxidizing Species. Antioxidants (Basel). 2019 Feb 22;8(2):48.
3. Akaike T et al. Enzymatic Regulation and Biological Functions of Reactive Cysteine Persulfides and Polysulfides. MDPI. 2020 Aug 27;9(9):444.
Read summarized clinical updates, watch expert medical content, and earn CME certifications right from your smartphone.
Open your smartphone camera to scan and install.
A comprehensive review of metal persulfides, detailing their unique chemistry and vital roles in biological signaling and sulfur metabolism....
3 months ago
Dendritic cells bridge innate and adaptive immunity in myocardial infarction. This review explores their pathological roles, circulating dynamics, novel tolerogenic interventions, and how standard cardiovascular medications modulate dendritic cells to improve post-infarction myocardial repair and patient outcomes.
Today
A premature neonate developed upper limb compartment syndrome after uterine rupture extruded the arm through a scar defect. Conservative management with continuous monitoring yielded complete functional recovery and normal limb growth at 10-year follow-up, highlighting non-operative safety in selected cases.
Today
Atherosclerosis involves extensive glycometabolic reprogramming across immune and vascular cells. This review examines how glycolysis, the pentose phosphate pathway, and lactate-driven epigenetic shifts fuel plaque vulnerability, while highlighting novel therapeutic targets like PFKFB3 and LDHA.
Today
Endoscopic posterior cervical fusion combines minimally invasive decompression, joint preparation, and rigid screw-rod fixation for atlantoaxial pathologies. Early clinical findings demonstrate solid bony union, excellent symptom relief, and minimal soft-tissue morbidity without significant vascular compromise.
Yesterday
The All-India Food Processors' Association has approached the Supreme Court to oppose FSSAI's proposed per-100g benchmark for front-of-pack warning labels, advocating instead for a per-serving threshold. We explore the regulatory showdown, nutritional evidence, and implications for clinical lifestyle counseling.
Today
