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As immunotherapy transforms oncology, intensivists face severe immune-mediated adverse events. This comprehensive review outlines critical care protocols for managing cytokine release syndrome, immune effector cell-associated neurotoxicity, and organ-specific toxicities in critically ill cancer patients.
A nationwide observational study compares Takotsubo syndrome with acute myocardial infarction across Spanish hospitals. Findings reveal distinct demographic profiles, lower crude in-hospital mortality, and critical diagnostic considerations essential for emergency and critical care clinicians.
A landmark ELSO Registry study examines pediatric ECMO circuit failure across 26,318 circuits. Discover the median time to mechanical failure, critical risk factors such as neonatal age and low weight, and the significant impact of circuit replacement on pediatric survival.
A toxicologic investigation reveals an outbreak of severe acquired methemoglobinemia caused by dermal absorption of the gasoline additive N-methylaniline in fuel-contaminated seawater. Understand the clinical presentation, urgent methylene blue management, and surveillance for delayed hemolytic anemia.
A landmark AHA study of 206,467 patients reveals marked hospital-level variation in post-ROSC survival (25.0% to 44.8%). Lower community social deprivation was associated with higher risk-standardized survival, highlighting critical targets for post-resuscitation quality improvement.
