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A real-world retrospective study demonstrates that adjunctive everolimus delivers sustained, long-term seizure reduction in TSC-associated epilepsy. Patients with fewer involved organ systems, lower baseline anti-seizure medication burdens, and younger ages experienced significantly more favorable clinical outcomes.
A prospective cohort study demonstrates that poor adolescent sleep quality, especially long sleep latency and reduced efficiency, increases dysmenorrhea severity in young adulthood. Addressing adolescent rest patterns offers a critical preventive avenue for clinicians.
A landmark ELSO Registry study examines pediatric ECMO circuit failure across 26,318 circuits. Discover the median time to mechanical failure, critical risk factors such as neonatal age and low weight, and the significant impact of circuit replacement on pediatric survival.
A research team from IISER Berhampur has engineered an advanced biosensor combining covalent organic frameworks and gold nanostars. This platform detects Turner syndrome genetic signatures rapidly, providing a scalable alternative to month-long karyotyping and enabling timely clinical interventions.
A multisite pilot in Kenya evaluated a paper-based neonatal risk predictor derived from machine learning. While 80% of providers praised its triage utility within 48 hours, high documentation burden and staffing shortages highlight the vital need for seamless workflow integration and administrative support.
