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A treat-and-extend strategy aims to maintain disease control in neovascular age-related macular degeneration while allowing treatment intervals to be individualised. This randomized clinical trial compared two different aflibercept extension strategies after a three-dose loading phase. Both protocols produced similar visual and anatomical outcomes at two years, while the faster extension approach reached longer intervals with fewer injections. The findings support the principle that treatment intervals can be extended safely in selected eyes when disease activity remains controlled. For HCPs, the value of treat-and-extend is not simply fewer injections; it is the ability to balance disease suppression with a lower treatment burden and fewer clinic visits. OCT remains essential for identifying recurrence before vision deteriorates. The study is particularly relevant to AIOC's retina curriculum because wet AMD management increasingly depends on practical scheduling strategies rather than a single fixed dosing pattern. Patient adherence, imaging quality and the ability to return promptly when symptoms change remain critical.
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A treat-and-extend strategy aims to maintain disease control in neovascular age-related macular degeneration while allowing treatment intervals to be individualised. This randomized clinical trial compared two different aflibercept extension strategies after a three-dose loading phase. Both protocols produced similar visual and anatomical outcomes at two years, while the faster extension approach reached longer intervals with fewer injections. The findings support the principle that treatment intervals can be extended safely in selected eyes when disease activity remains controlled. For HCPs, the value of treat-and-extend is not simply fewer injections; it is the ability to balance disease suppression with a lower treatment burden and fewer clinic visits. OCT remains essential for identifying recurrence before vision deteriorates. The study is particularly relevant to AIOC's retina curriculum because wet AMD management increasingly depends on practical scheduling strategies rather than a single fixed dosing pattern. Patient adherence, imaging quality and the ability to return promptly when symptoms change remain critical.
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