.webp&w=384&q=75){kind=logo}
Loading, please wait...
Loading, please wait...
A treat-and-extend strategy aims to maintain disease control in neovascular age-related macular degeneration while allowing treatment intervals to be individualised. This randomized clinical trial compared two different aflibercept extension strategies after a three-dose loading phase. Both protocols produced similar visual and anatomical outcomes at two years, while the faster extension approach reached longer intervals with fewer injections. The findings support the principle that treatment intervals can be extended safely in selected eyes when disease activity remains controlled. For HCPs, the value of treat-and-extend is not simply fewer injections; it is the ability to balance disease suppression with a lower treatment burden and fewer clinic visits. OCT remains essential for identifying recurrence before vision deteriorates. The study is particularly relevant to AIOC's retina curriculum because wet AMD management increasingly depends on practical scheduling strategies rather than a single fixed dosing pattern. Patient adherence, imaging quality and the ability to return promptly when symptoms change remain critical.
Read summarized clinical updates, watch expert medical content, and earn CME certifications right from your smartphone.
Open your smartphone camera to scan and install.
A treat-and-extend strategy aims to maintain disease control in neovascular age-related macular degeneration while allowing treatment intervals to be individualised. This randomized clinical trial compared two different aflibercept extension strategies after a three-dose loading phase. Both protocols produced similar visual and anatomical outcomes at two years, while the faster extension approach reached longer intervals with fewer injections. The findings support the principle that treatment intervals can be extended safely in selected eyes when disease activity remains controlled. For HCPs, the value of treat-and-extend is not simply fewer injections; it is the ability to balance disease suppression with a lower treatment burden and fewer clinic visits. OCT remains essential for identifying recurrence before vision deteriorates. The study is particularly relevant to AIOC's retina curriculum because wet AMD management increasingly depends on practical scheduling strategies rather than a single fixed dosing pattern. Patient adherence, imaging quality and the ability to return promptly when symptoms change remain critical.
4 weeks back
A bioengineered oral nanozyme microsupplement converts pathological ROS into a protective polydopamine hydrogel shield. By curbing neutrophil extracellular traps and balancing T cells, this platform outperforms standard 5-ASA in preclinical colitis models, opening new paths for sustained remission.
4 days back
Recent research reveals that downregulating YAP1/TAZ-TEAD via Hippo signaling triggers spontaneous human trophoblast syncytialization in 3D cultures, illuminating placental biology and preeclampsia.
4 weeks back
Abdominal aortic aneurysm rupture remains a catastrophic vascular emergency. Groundbreaking research reveals that USP53 accelerates aneurysm progression by reprogramming smooth muscle cell metabolism toward aerobic glycolysis, highlighting a promising target beyond conventional diameter-based surveillance.
5 days back
A breakthrough study leverages natural language processing to accurately identify incident medication-related osteonecrosis of the jaw and track antiresorptive drug holidays from clinical narratives in electronic health records, advancing osteoporosis pharmacovigilance and dental safety.
4 days back
Recent research defines ferro-aging as a conserved iron-lipid axis driving organ decline across primates. Age-related iron dyshomeostasis stimulates ACSL4-mediated lipid peroxidation, promoting cellular senescence. Notably, vitamin C directly inhibits ACSL4, suppressing phospholipid oxidation and multi-organ decay.
5 days back
