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This multicentre, randomised clinical trial conducted at 12 outpatient neurology clinics in the United States and China evaluated an artificial intelligence-driven transcutaneous peripheral nerve stimulation (TPNS) device for adults with essential tremor affecting the upper limbs. Participants were randomised in a 2:1 ratio to active stimulation (n=83) or sham stimulation (n=42) and instructed to use the wearable device during waking hours for 90 days. The primary endpoint was change from baseline in the modified Activities of Daily Living (mADL) subscale of the Essential Tremor Rating Assessment Scale at day 90. Among 125 randomised participants, mean tremor duration was 11.4 years. At 90 days, mADL scores decreased by 6.9 points with active TPNS (95% CI, 5.4–8.4) compared with 2.7 points with sham stimulation
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This multicentre, randomised clinical trial conducted at 12 outpatient neurology clinics in the United States and China evaluated an artificial intelligence-driven transcutaneous peripheral nerve stimulation (TPNS) device for adults with essential tremor affecting the upper limbs. Participants were randomised in a 2:1 ratio to active stimulation (n=83) or sham stimulation (n=42) and instructed to use the wearable device during waking hours for 90 days. The primary endpoint was change from baseline in the modified Activities of Daily Living (mADL) subscale of the Essential Tremor Rating Assessment Scale at day 90. Among 125 randomised participants, mean tremor duration was 11.4 years. At 90 days, mADL scores decreased by 6.9 points with active TPNS (95% CI, 5.4–8.4) compared with 2.7 points with sham stimulation
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