.webp&w=384&q=75){kind=logo}
Loading, please wait...
Loading, please wait...
SPRINT randomized more than 9,000 adults at increased cardiovascular risk to an intensive systolic blood-pressure target below 120 mmHg or a standard target below 140 mmHg. Intensive treatment significantly reduced the composite cardiovascular outcome and all-cause mortality. The study reshaped the discussion around blood-pressure targets, while also highlighting the potential trade-offs of more intensive therapy, including hypotension, syncope, electrolyte abnormalities and acute kidney injury. For general physicians, SPRINT is best interpreted as a framework for selected high-risk patients rather than a universal target applied without context. Accurate measurement technique is essential, and treatment intensity should reflect age, frailty, orthostatic symptoms, kidney function and overall cardiovascular risk. The trial's importance to resistant-hypertension discussions is also conceptual: reaching lower targets often requires combination therapy and attention to adherence, sodium intake, sleep, weight and secondary causes. In routine practice, the value of a target depends on the quality of the measurement and the consistency with which therapy is monitored and adjusted.
Read summarized clinical updates, watch expert medical content, and earn CME certifications right from your smartphone.
Open your smartphone camera to scan and install.
SPRINT randomized more than 9,000 adults at increased cardiovascular risk to an intensive systolic blood-pressure target below 120 mmHg or a standard target below 140 mmHg. Intensive treatment significantly reduced the composite cardiovascular outcome and all-cause mortality. The study reshaped the discussion around blood-pressure targets, while also highlighting the potential trade-offs of more intensive therapy, including hypotension, syncope, electrolyte abnormalities and acute kidney injury. For general physicians, SPRINT is best interpreted as a framework for selected high-risk patients rather than a universal target applied without context. Accurate measurement technique is essential, and treatment intensity should reflect age, frailty, orthostatic symptoms, kidney function and overall cardiovascular risk. The trial's importance to resistant-hypertension discussions is also conceptual: reaching lower targets often requires combination therapy and attention to adherence, sodium intake, sleep, weight and secondary causes. In routine practice, the value of a target depends on the quality of the measurement and the consistency with which therapy is monitored and adjusted.
3 weeks back
Discover how catalytic nanozymes redefine autoimmune disease therapy by establishing a physiological redox set-point to restore immune tolerance without broad immunosuppression.
Last week
Recent research reveals that downregulating YAP1/TAZ-TEAD via Hippo signaling triggers spontaneous human trophoblast syncytialization in 3D cultures, illuminating placental biology and preeclampsia.
3 weeks back
A landmark comparative study evaluates atrial electrophysiology across humans, swine, and rodents. By linking cellular recordings with transcriptomics and in silico modeling, researchers resolve cross-species gaps, explaining translational failures to advance targeted therapies for atrial arrhythmias.
3 weeks back
A novel pathology-adaptive surface engineering strategy uses functionalized plasma polymer coatings to selectively modulate AGE adsorption, reducing oxidative stress and restoring bone formation in diabetic and aging microenvironments.
last month
Researchers have developed an innovative ultrasound-responsive nano-contrast agent that co-delivers CIITA-siRNA and rapamycin directly to inflamed thyroid tissue, significantly reducing autoimmune injury and thyroid autoantibodies in preclinical models of Hashimoto thyroiditis.
3 weeks back
