.webp&w=384&q=75){kind=logo}
Loading, please wait...
Loading, please wait...
This study evaluated health-related quality of life (HRQOL) in 126 adults aged 18–85 years with remitted psychotic depression who had initially achieved remission with sertraline plus olanzapine. Participants were randomized to continue sertraline plus olanzapine or sertraline plus placebo. The combination produced significantly better outcomes in the Role Emotional (RE) and Mental Health (MH) SF-36 domains. Relapse was associated with marked deterioration in both domains; approximately one-quarter of participants receiving sertraline plus placebo had RE and MH scores >2 SD below population norms at study termination. The findings support continued combination therapy for maintaining psychological HRQOL.
Read summarized clinical updates, watch expert medical content, and earn CME certifications right from your smartphone.
Open your smartphone camera to scan and install.
This study evaluated health-related quality of life (HRQOL) in 126 adults aged 18–85 years with remitted psychotic depression who had initially achieved remission with sertraline plus olanzapine. Participants were randomized to continue sertraline plus olanzapine or sertraline plus placebo. The combination produced significantly better outcomes in the Role Emotional (RE) and Mental Health (MH) SF-36 domains. Relapse was associated with marked deterioration in both domains; approximately one-quarter of participants receiving sertraline plus placebo had RE and MH scores >2 SD below population norms at study termination. The findings support continued combination therapy for maintaining psychological HRQOL.
Today
A bioengineered oral nanozyme microsupplement converts pathological ROS into a protective polydopamine hydrogel shield. By curbing neutrophil extracellular traps and balancing T cells, this platform outperforms standard 5-ASA in preclinical colitis models, opening new paths for sustained remission.
Yesterday
Recent research reveals that downregulating YAP1/TAZ-TEAD via Hippo signaling triggers spontaneous human trophoblast syncytialization in 3D cultures, illuminating placental biology and preeclampsia.
3 weeks back
Abdominal aortic aneurysm rupture remains a catastrophic vascular emergency. Groundbreaking research reveals that USP53 accelerates aneurysm progression by reprogramming smooth muscle cell metabolism toward aerobic glycolysis, highlighting a promising target beyond conventional diameter-based surveillance.
2 days back
A breakthrough study leverages natural language processing to accurately identify incident medication-related osteonecrosis of the jaw and track antiresorptive drug holidays from clinical narratives in electronic health records, advancing osteoporosis pharmacovigilance and dental safety.
2 days back
Recent research defines ferro-aging as a conserved iron-lipid axis driving organ decline across primates. Age-related iron dyshomeostasis stimulates ACSL4-mediated lipid peroxidation, promoting cellular senescence. Notably, vitamin C directly inhibits ACSL4, suppressing phospholipid oxidation and multi-organ decay.
3 days back
