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Randomized trials of preimplantation genetic testing for aneuploidy (PGT-A) show a nuanced picture. In some IVF populations, selecting euploid embryos can reduce the number of embryos transferred and may improve implantation efficiency, but randomized evidence has not established a universal increase in cumulative live-birth rate for all patients. For reproductive specialists, the value of PGT-A depends on maternal age, embryo yield, laboratory quality and the goal of treatment. PGT-A is a screening test applied to embryo biopsy material and is not a guarantee of a chromosomally normal fetus. Genetic counseling remains important, especially when mosaic or inconclusive results occur. The clinical discussion should therefore focus on the individual probability of obtaining transferable embryos, time to pregnancy and cumulative outcomes rather than assuming that more genetic information always produces a higher live-birth rate.
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Randomized trials of preimplantation genetic testing for aneuploidy (PGT-A) show a nuanced picture. In some IVF populations, selecting euploid embryos can reduce the number of embryos transferred and may improve implantation efficiency, but randomized evidence has not established a universal increase in cumulative live-birth rate for all patients. For reproductive specialists, the value of PGT-A depends on maternal age, embryo yield, laboratory quality and the goal of treatment. PGT-A is a screening test applied to embryo biopsy material and is not a guarantee of a chromosomally normal fetus. Genetic counseling remains important, especially when mosaic or inconclusive results occur. The clinical discussion should therefore focus on the individual probability of obtaining transferable embryos, time to pregnancy and cumulative outcomes rather than assuming that more genetic information always produces a higher live-birth rate.
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